Bichromatic tetraphasic optical coherence microscopy for full-field single-shot imaging of biological dynamics

Rishyashring R. Iyer; Mantas Žurauskas; Eric J. Chaney; Stephen A. Boppart

doi:10.1117/12.3000645

13 March 2024 Bichromatic tetraphasic optical coherence microscopy for full-field single-shot imaging of biological dynamics

Rishyashring R. Iyer, Mantas Žurauskas, Eric J. Chaney, Stephen A. Boppart

Author Affiliations +

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC1283025 (2024) https://doi.org/10.1117/12.3000645
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We present a novel optical coherence microscopy (OCM) setup capable of generating dynamic intensity, phase, and pseudo-spectroscopic contrast with single-shot full-field video-rate imaging called BiTe (Bichromatic Tetraphasic) full-field OCM. BiTe OCM uniquely uses the phase-shifting properties of AR coatings outside their rated bandwidths to create four distinct phase shifts between the sample and reference. BiTe OCM utilizes the raw data effectively to generate three complementary contrasts. We demonstrate BiTe OCM to observe cellular dynamics, capture the spectroscopic hemodynamics of tumors, and image the microstructure of fall foliage in two different color channels.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Rishyashring R. Iyer, Mantas Žurauskas, Eric J. Chaney, and Stephen A. Boppart "Bichromatic tetraphasic optical coherence microscopy for full-field single-shot imaging of biological dynamics", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC1283025 (13 March 2024); https://doi.org/10.1117/12.3000645

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KEYWORDS

Biological imaging

Optical coherence microscopy

Phase shifts

Spatial resolution

Speckle

Spectroscopy

Tissue optics

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