Photoacoustic imaging of the hemodynamic responses in the squirrel monkey brain induced by peripheral mechanical stimulation

Kai-Wei Chang; Madhumithra Subramanian Karthikesh; Yunhao Zhu; Heather M. Hudson; Scott Barbay; David T. Bundy; David J. Guggenmos; Shawn Frost; Randolph J. Nudo; Xinmai Yang; Xueding Wang

doi:10.1117/12.3001003

13 March 2024 Photoacoustic imaging of the hemodynamic responses in the squirrel monkey brain induced by peripheral mechanical stimulation

Kai-Wei Chang, Madhumithra Subramanian Karthikesh, Yunhao Zhu, Heather M. Hudson, Scott Barbay, David T. Bundy, David J. Guggenmos, Shawn Frost, Randolph J. Nudo, Xinmai Yang, Xueding Wang

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128420K (2024) https://doi.org/10.1117/12.3001003
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

This study illustrates the potential of non-invasive Photoacoustic Microscopy (PAM) to monitor functional changes in a squirrel monkey brain due to peripheral mechanical stimulation. Our unique approach employs a deep Fully Convolutional Neural Network (FCNN) to significantly enhance PAM image quality, improving signal-to-noise ratio and structural similarity index. Notably, functional changes induced by peripheral mechanical stimulation were effectively observed. The study showcases the potential of PAM in neurological applications, advancing our understanding of brain hemodynamics, and the transformative effect of machine learning techniques on PAM image quality, opening new possibilities for future neuroscientific research.

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Kai-Wei Chang, Madhumithra Subramanian Karthikesh, Yunhao Zhu, Heather M. Hudson, Scott Barbay, David T. Bundy, David J. Guggenmos, Shawn Frost, Randolph J. Nudo, Xinmai Yang, and Xueding Wang "Photoacoustic imaging of the hemodynamic responses in the squirrel monkey brain induced by peripheral mechanical stimulation", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128420K (13 March 2024); https://doi.org/10.1117/12.3001003

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