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13 March 2024 Photoacoustic microscopy and fluorescence microscopy dual-modality imaging of brain biomarkers in mice with Alzheimer's disease
Tianqu Zhai, Wei Zhang, Yannis M. Paulus, Enming J. Su, Geoffrey Murphy, Daniel A. Lawrence, Xueding Wang
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Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128420N (2024) https://doi.org/10.1117/12.3000242
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder usually accompanied by buildup of amyloid-beta (Aβ) plaques and neurofibrillary tangles, cerebral vascular morphological and functional changes. Our study presents a combined photoacoustic microscopy and fluorescence microscopy dual-modality imaging system for in-vivo monitoring of biomarkers for AD via cranial window. Photoacoustic microscopy resolves vasculature, blood oxygenation and flow speed at capillary level, while a confocally designed fluorescence microscope, aided by an Aβ targeting dye, maps the distribution of Aβ plaques. Results with age-varied AD mice group showed reduced vessel density, decreased perfusion at distal capillaries, and increased plaque density compared to wild type mice. This technique provides guidance for longitudinal monitoring of AD progression.
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Tianqu Zhai, Wei Zhang, Yannis M. Paulus, Enming J. Su, Geoffrey Murphy, Daniel A. Lawrence, and Xueding Wang "Photoacoustic microscopy and fluorescence microscopy dual-modality imaging of brain biomarkers in mice with Alzheimer's disease", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128420N (13 March 2024); https://doi.org/10.1117/12.3000242
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KEYWORDS
Alzheimer disease
Brain
Fluorescence imaging
Fluorescence microscopy
Neuroimaging
Photoacoustic imaging
Photoacoustic microscopy
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