Enabling longitudinal quantitative photoacoustic mesoscopy of vascular networks through image co-registration

Thierry L. Lefebvre; Paul W. Sweeney; Janek Gröhl; Lina Hacker; Emma L. Brown; Thomas R. Else; Mariam-Eleni Oraiopoulou; Algernon Bloom; David Y. Lewis; Sarah E. Bohndiek

doi:10.1117/12.3002744

13 March 2024 Enabling longitudinal quantitative photoacoustic mesoscopy of vascular networks through image co-registration

Thierry L. Lefebvre, Paul W. Sweeney, Janek Gröhl, Lina Hacker, Emma L. Brown, Thomas R. Else, Mariam-Eleni Oraiopoulou, Algernon Bloom, David Y. Lewis, Sarah E. Bohndiek

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128421G (2024) https://doi.org/10.1117/12.3002744
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Longitudinal mesoscopic photoacoustic imaging of vascular networks requires accurate image co-registration to assess local changes in growing tumours, but remains challenging due to sparsity of data and scan-to-scan variability. Here, we compared a set of 5 curated co-registration methods applied to 49 pairs of vascular images of mouse ears and breast cancer xenografts. Images were segmented using a generative adversarial network and pairs of images and/or segmentations were fed into the 5 tested algorithms. We show the feasibility of co-registering vascular networks accurately using a range of quality metrics, taking a step towards longitudinal characterization of those complex structures.

Conference Presentation

Citation Download Citation

Thierry L. Lefebvre, Paul W. Sweeney, Janek Gröhl, Lina Hacker, Emma L. Brown, Thomas R. Else, Mariam-Eleni Oraiopoulou, Algernon Bloom, David Y. Lewis, and Sarah E. Bohndiek "Enabling longitudinal quantitative photoacoustic mesoscopy of vascular networks through image co-registration", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128421G (13 March 2024); https://doi.org/10.1117/12.3002744

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