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13 March 2024 Longitudinal intravital monitoring for angiogenesis in fibrin scaffolds using non-invasive in vivo photoacoustic microscopy and optical coherence tomography
Zhanpeng Xu, Wei Zhang, Carole Quesada, Mario Fabiilli, Xueding Wang
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Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128421O (2024) https://doi.org/10.1117/12.2692830
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
In this work, a PAM and OCT combined dual-modality imaging system was applied for non-invasive in vivo imaging of angiogenesis. Two groups of fibrin scaffolds, with and without basic fibroblast growth factor (bFGF), were implanted and covered by transparent imaging window for longitudinal observation. Imaging experiments were conducted on days 3, 5, 7, and 9 to monitor vascularization. Several vasculature related parameters were statistically compared and significant differences were discovered, indicating the effect of bFGF in promoting angiogenesis. By counting the vessel density in histological sections, similar statistical results consistent with the imaging was acquired, further validating the imaging accuracy.
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Zhanpeng Xu, Wei Zhang, Carole Quesada, Mario Fabiilli, and Xueding Wang "Longitudinal intravital monitoring for angiogenesis in fibrin scaffolds using non-invasive in vivo photoacoustic microscopy and optical coherence tomography", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128421O (13 March 2024); https://doi.org/10.1117/12.2692830
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KEYWORDS
Biological imaging
In vivo imaging
Optical coherence tomography
Photoacoustic microscopy
Optical sensing
Imaging systems
Tissues
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