Photodynamic priming synergizes with anti-PD1 therapy to improve survival in a preclinical pancreatic tumor model

Mohammad A. Saad; Tessa D. van Bergen; Jimena Nicolás Morala; Harrison J. Roberts; Derek Allen; Zhiming Mai; Tayyaba Hasan

doi:10.1117/12.3003546

13 March 2024 Photodynamic priming synergizes with anti-PD1 therapy to improve survival in a preclinical pancreatic tumor model

Mohammad A. Saad, Tessa D. van Bergen, Jimena Nicolás Morala, Harrison J. Roberts, Derek Allen, Zhiming Mai, Tayyaba Hasan

Author Affiliations +

Proceedings Volume PC12843, Biophotonics and Immune Responses XIX; PC1284307 (2024) https://doi.org/10.1117/12.3003546
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia which is considered to be a primary cause of treatment resistance observed in these tumors. Desmoplasia also plays a major role in mediating an immunosuppressive microenvironment and restricting immune cell infiltration in PDAC. In this study, using a syngeneic orthotopic immunocompetent KPC PDAC model, we demonstrate that PDT using Visudyne® can alter the tumor microenvironment, enhances immune cell infiltration, significantly reducing tumor growth and increasing survival in combination with anti-PD1.

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Mohammad A. Saad, Tessa D. van Bergen, Jimena Nicolás Morala, Harrison J. Roberts, Derek Allen, Zhiming Mai, and Tayyaba Hasan "Photodynamic priming synergizes with anti-PD1 therapy to improve survival in a preclinical pancreatic tumor model", Proc. SPIE PC12843, Biophotonics and Immune Responses XIX, PC1284307 (13 March 2024); https://doi.org/10.1117/12.3003546

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