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13 March 2024 Imaging biomechanics with multimodal Brillouin-OCT system during neural tube morphogenesis
Yogeshwari S. Ambekar, Carlo Donato Caiaffa, Manmohan Singh, Alexander W. Schill, John Steele, Bogdan Wlodarczyk, Salavat R. Aglyamov, Giuliano Scarcelli, Richard H. Finnell, Kirill V. Larin
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Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC128440A (2024) https://doi.org/10.1117/12.3002782
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Neural tube closure (NTC) is a highly synchronized morphological process driven by mechanical forces, and any disruptions during this process can lead to neural tube defects (NTDs). However, mechanical properties associated with NTDs are largely unknown. To understand the correlation between NTDs and biomechanical properties, we imaged NTC using multimodal Brillouin microscopy and optical coherence tomography in two mutant mice lines, where the genes Mthfd1l and Fuz were inactivated. We also imaged cerebral organoids cultured in dolutegravir for 10 and 14 days. Our results showed a clear link between NTDs and neural tube biomechanical properties.
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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Yogeshwari S. Ambekar, Carlo Donato Caiaffa, Manmohan Singh, Alexander W. Schill, John Steele, Bogdan Wlodarczyk, Salavat R. Aglyamov, Giuliano Scarcelli, Richard H. Finnell, and Kirill V. Larin "Imaging biomechanics with multimodal Brillouin-OCT system during neural tube morphogenesis", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440A (13 March 2024); https://doi.org/10.1117/12.3002782
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KEYWORDS
Imaging systems
Biomechanics
Multimodal imaging
Nervous system
Animal model studies
Optical coherence tomography
Genetics
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