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13 March 2024 Correlations between intraocular pressure regulation and the biomechanical behaviors of perilimbal sclera and distal vasculatures
Guan Xu, Linyu Ni, Alexus Warchock, Erik Krawczyk, Wonsuk Kim, Sayoko E. Moroi, Alan Argento
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Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC128440J (2024) https://doi.org/10.1117/12.3003230
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Glaucoma is a leading cause of blindness. Previously, we quantified the deformations in scleral tissue components through a PAM-FEA methodology. This study furthers our examination of perilimbal sclera (PLS) and aqueous veins in intraocular pressure (IOP) regulation using ex vivo porcine eyes. Our results reveal that the cross-sectional area change of the aqueous veins and strain of PLS are strongly and positively correlated with the steady-state IOP (n=8, R2=0.90, R2=0.57, respectively) and the IOP elevation rate at a constantly increasing flow rate (n=8, R2=0.89, R2=0.58, respectively). These findings support our hypothesis that the PLS and aqueous veins with less deformation are correlated with elevated steady state IOP and less adaptive behavior of eyes to increased aqueous outflow.
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Guan Xu, Linyu Ni, Alexus Warchock, Erik Krawczyk, Wonsuk Kim, Sayoko E. Moroi, and Alan Argento "Correlations between intraocular pressure regulation and the biomechanical behaviors of perilimbal sclera and distal vasculatures", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440J (13 March 2024); https://doi.org/10.1117/12.3003230
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KEYWORDS
Veins
Sclera
Biomechanics
Deformation
Finite element methods
Glaucoma
Tissues
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