Innovating intraoperative diagnostics and therapy: a triad of AI, femtosecond ablation and non-linear multimodal imaging

Jürgen Popp

doi:10.1117/12.3001409

13 March 2024 Innovating intraoperative diagnostics and therapy: a triad of AI, femtosecond ablation and non-linear multimodal imaging

Jürgen Popp

Author Affiliations +

Proceedings Volume PC12847, Multiphoton Microscopy in the Biomedical Sciences XXIV; PC1284703 (2024) https://doi.org/10.1117/12.3001409
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Multi-photon imaging offer a large potential to characterize both the morphology and molecular composition (= morphochemistry) of cells or tissue. Particularly interesting is the establishment of multimodal nonlinear microscopy for medical purposes. Investigating tissues of different morphochemistry underlines the versatility of non-linear multimodal imaging, e.g., to distinguish between healthy tissue and tissue altered by tumors, or drugs. Here, we show that the interplay between multimodal nonlinear imaging (CARS, TPEF, SHG) either in a microscopic or endoscopic setting in combination with innovative artificial intelligence approaches and fs-laser ablation opens exciting new ways for an intraoperative histopathological tissue analysis and selective removal.

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Jürgen Popp "Innovating intraoperative diagnostics and therapy: a triad of AI, femtosecond ablation and non-linear multimodal imaging", Proc. SPIE PC12847, Multiphoton Microscopy in the Biomedical Sciences XXIV, PC1284703 (13 March 2024); https://doi.org/10.1117/12.3001409

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KEYWORDS

Femtosecond phenomena

Artificial intelligence

Multimodal imaging

Tissues

Ablation

Biological imaging

Diagnostics

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