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13 March 2024 Multimodal chemical imaging for tracking subcellular metabolic dynamics
Hyeon Jeong Lee
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Proceedings Volume PC12855, Advanced Chemical Microscopy for Life Science and Translational Medicine 2024; PC128550I (2024) https://doi.org/10.1117/12.3003596
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Understanding metabolite dynamics in living systems is crucial for biomedical research. Fluorescence-based imaging has contributed tremendously to revealing mechanisms of organelle trafficking and interactions, however, not all biomolecules or organelles are labeled efficiently simultaneously without substantial perturbation from the labeling molecules. Vibrational spectroscopic imaging techniques are increasingly recognized as unique tools for investigating biomolecules in their natural microenvironment. Here, we developed a fluorescence-guided multimodal imaging approach to study organelle distribution and compositional changes in single cells. These advancements enable quantitative mapping of chemical dynamics, providing insights into subcellular biomolecule dynamics and mechanisms regulating cell physiology.
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Hyeon Jeong Lee "Multimodal chemical imaging for tracking subcellular metabolic dynamics", Proc. SPIE PC12855, Advanced Chemical Microscopy for Life Science and Translational Medicine 2024, PC128550I (13 March 2024); https://doi.org/10.1117/12.3003596
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KEYWORDS
Imaging spectroscopy
Biomolecules
Biomedical optics
Molecular interactions
Molecular spectroscopy
Molecules
Multimodal imaging
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