Khouloud Arfaoui,1 Nicolas Villa,2 Enrico Tartari,2 Simon Glicenstein,3 Emmanuel Picard,3 Grégory Resch,4 Emmanuel Hadji,3 Pierre R. Marcouxhttps://orcid.org/0000-0003-3855-9662,3 Romuald Houdré,2 Valérie Stambouli,5 Marc Zelsmann1
1Lab. des Technologies de la Microélectronique (France) 2Ecole Polytechnique Fédérale de Lausanne (Switzerland) 3CEA (France) 4Lab. of bacteriophages and phage therapy, CRISP (Switzerland) 5Lab. des Materiaux et du Genie Physique (France)
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Multidrug-resistant bacteria stem from the massive use of non-specific antibiotics prescribed to manage bacterial infections. The therapeutic use of viruses called bacteriophages is a promising complementary and personalised strategy requiring very accurate phage selection for patient administration. Therefore, we are developing an interdisciplinary methodology for phage susceptibility testing (PST) based on bio-photonic microsystems. We demonstrated the use of on-chip optical photonic crystals on silicon-on-insulator (SOI) for the spatial confinement of bacteria and phages. We will present our state of the art of this project and the methods currently used to study the interactions between SOI and biological objects.
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Khouloud Arfaoui, Nicolas Villa, Enrico Tartari, Simon Glicenstein, Emmanuel Picard, Grégory Resch, Emmanuel Hadji, Pierre R. Marcoux, Romuald Houdré, Valérie Stambouli, Marc Zelsmann, "Trapping of biological objects on SOI optical photonic crystal micro-resonators," Proc. SPIE PC13008, Biophotonics in Point-of-Care III, PC1300809 (20 June 2024); https://doi.org/10.1117/12.3022382