Optical probes and techniques for molecular contrast enhancement in coherence imaging

Stephen A. Boppart M.D.; Amy L. Oldenburg; Chenyang Xu; Daniel L. Marks

doi:10.1117/1.2008974

1 July 2005 Optical probes and techniques for molecular contrast enhancement in coherence imaging

Stephen A. Boppart M.D., Amy L. Oldenburg, Chenyang Xu, Daniel L. Marks

Author Affiliations +

Journal of Biomedical Optics, Vol. 10, Issue 4, 041208 (July 2005). https://doi.org/10.1117/1.2008974

Abstract

Optics has played a key role in the rapidly developing field of molecular imaging. The spectroscopic nature and high-resolution imaging capabilities of light provide a means for probing biological morphology and function at the cellular and molecular levels. While the use of bioluminescent and fluorescent probes has become a mainstay in optical molecular imaging, a large number of other optical imaging modalities exist that can be included in this emerging field. In vivo imaging technologies such as optical coherence tomography and reflectance confocal microscopy have had limited use of molecular probes. In the last few years, novel nonfluorescent and nonbioluminescent molecular imaging probes have been developed that will initiate new directions in coherent optical molecular imaging. Classes of probes reviewed in this work include those that alter the local optical scattering or absorption properties of the tissue, those that modulate these local optical properties in a predictable manner, and those that are detected utilizing spectroscopic optical coherence tomography (OCT) principles. In addition to spectroscopic OCT, novel nonlinear interferometric imaging techniques have recently been developed to detect endogenous molecules. Probes and techniques designed for coherent molecular imaging are likely to improve the detection and diagnostic capabilities of OCT.

©(2005) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Stephen A. Boppart M.D., Amy L. Oldenburg, Chenyang Xu, and Daniel L. Marks "Optical probes and techniques for molecular contrast enhancement in coherence imaging," Journal of Biomedical Optics 10(4), 041208 (1 July 2005). https://doi.org/10.1117/1.2008974

Published: 1 July 2005

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
14 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 140 scholarly publications and 5 patents.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Optical coherence tomography

Scattering

Tissue optics

Absorption

Tissues

Signal detection

Molecules

Show All Keywords

RELATED CONTENT

Nanoparticle enhanced spectral photoacoustic tomography effect of oxygen saturation...
Proceedings of SPIE (March 15 2016)

Effect of reference spectra in spectral fitting to discriminate enzyme...
Proceedings of SPIE (March 15 2016)

Analysis of nanoparticles optical propagation influence in biological tissue simulating...
Proceedings of SPIE (February 15 2017)

Nanoshells for integrated diagnosis and therapy of cancer
Proceedings of SPIE (December 29 2004)

Optical characterization and feasibility study of multifunctional polylactic co glycolic...
Proceedings of SPIE (June 17 2011)

Fiber probes based optical techniques for biomedical diagnosis
Proceedings of SPIE (July 09 2007)

Imaging site specific peptide targeting in tumor tissues using spectral...
Proceedings of SPIE (February 21 2011)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years