CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 12 > Issue 4 > Article
Open Access
1 July 2007 Sensitive biosensor array using surface plasmon resonance on metallic nanoslits
Kuang-Li Lee, Chia-Wei Lee, Way-Seen Wang, Pei-Kuan Wei
Author Affiliations +
Journal of Biomedical Optics, Vol. 12, Issue 4, 044023 (July 2007). https://doi.org/10.1117/1.2772296
Abstract
Chip-based biosensor arrays for label-free and high-throughput detection were fabricated and tested. The sensor array was composed of a 150-nm-thick, 50-nm-gap, and 600-nm-period gold nanoslits. Each array size was 100 μm×100 μm. A transverse-magnetic polarized wave in these metallic nanostructures generated resonant surface plasmons at a wavelength of about 800 nm in a water environment. Using the resonant wavelength shift in the nanoslit array, we achieved detection sensitivity up to 668 nm per refractive index unit, about 1.7 times larger than that reported on an array of nanoholes. An antigen–antibody interaction experiment in an aqueous environment verified the sensitivity in a surface binding event.
©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Kuang-Li Lee, Chia-Wei Lee, Way-Seen Wang, and Pei-Kuan Wei "Sensitive biosensor array using surface plasmon resonance on metallic nanoslits," Journal of Biomedical Optics 12(4), 044023 (1 July 2007). https://doi.org/10.1117/1.2772296
Published: 1 July 2007
JOURNAL ARTICLE
 5 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 126 scholarly publications and 2 patents.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Gold
Surface plasmons
Biosensors
Water
Glasses
Refractive index
Nanolithography
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top