CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 13 > Issue 6 > Article
Open Access
1 November 2008 Photoacoustic monitoring of burn healing process in rats
Kazuya Aizawa, Shunichi Sato, Daizoh Saitoh, Hiroshi Ashida, Minoru Obara
Author Affiliations +
Journal of Biomedical Optics, Vol. 13, Issue 6, 064020 (November 2008). https://doi.org/10.1117/1.3028005
Abstract
We performed multiwavelength photoacoustic (PA) measurement for extensive deep dermal burns in rats to monitor the healing process of the wounds. The PA signal peak at 532 nm, an isosbestic point for oxyhemoglobin (HbO2) and deoxyhemoglobin (HHb), was found to shift to a shallower region of the injured skin tissue with the elapse of time. The results of histological analysis showed that the shift of the PA signal reflected angiogenesis in the wounds. Until 24 h postburn, PA signal amplitude generally increased at all wavelengths. We speculate that this increase in amplitude is associated with dilation of blood vessels within healthy tissue under the injured tissue layer and increased hematocrit value due to development of edema. From 24 to 48 h postburn, the PA signal showed wavelength-dependent behaviors; signal amplitudes at 532, 556, and 576 nm continued to increase, while amplitude at 600 nm, an HHb absorption-dominant wavelength, decreased. This seems to reflect change from shock phase to hyperdynamic state in the rat; in the hyperdynamic state, cardiac output and oxygen consumption increased considerably. These findings show that multiwavelength PA measurement would be useful for monitoring recovery of perfusion and change in local hemodynamics in the healing process of burns.
©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Kazuya Aizawa, Shunichi Sato, Daizoh Saitoh, Hiroshi Ashida, and Minoru Obara "Photoacoustic monitoring of burn healing process in rats," Journal of Biomedical Optics 13(6), 064020 (1 November 2008). https://doi.org/10.1117/1.3028005
Published: 1 November 2008
JOURNAL ARTICLE
 7 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 30 scholarly publications and 1 patent.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Tissues
Blood
Photoacoustic spectroscopy
Skin
Wound healing
Hemodynamics
Injuries
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top