CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 14 > Issue 6 > Article
Open Access
1 November 2009 Noninvasive assessment of diabetic foot ulcers with diffuse photon density wave methodology: pilot human study
Elisabeth S. Papazoglou, Michael T. Neidrauer, Leonid Zubkov, Michael S. Weingarten M.D., Kambiz Pourrezaei
Author Affiliations +
Journal of Biomedical Optics, Vol. 14, Issue 6, 064032 (November 2009). https://doi.org/10.1117/1.3275467
Abstract
A pilot human study is conducted to evaluate the potential of using diffuse photon density wave (DPDW) methodology at near-infrared (NIR) wavelengths (685 to 830 nm) to monitor changes in tissue hemoglobin concentration in diabetic foot ulcers. Hemoglobin concentration is measured by DPDW in 12 human wounds for a period ranging from 10 to 61 weeks. In all wounds that healed completely, gradual decreases in optical absorption coefficient, oxygenated hemoglobin concentration, and total hemoglobin concentration are observed between the first and last measurements. In nonhealing wounds, the rates of change of these properties are nearly zero or slightly positive, and a statistically significant difference (p<0.05) is observed in the rates of change between healing and nonhealing wounds. Differences in the variability of DPDW measurements over time are observed between healing and nonhealing wounds, and this variance may also be a useful indicator of nonhealing wounds. Our results demonstrate that DPDW methodology with a frequency domain NIR device can differentiate healing from nonhealing diabetic foot ulcers, and indicate that it may have clinical utility in the evaluation of wound healing potential.
©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Elisabeth S. Papazoglou, Michael T. Neidrauer, Leonid Zubkov, Michael S. Weingarten M.D., and Kambiz Pourrezaei "Noninvasive assessment of diabetic foot ulcers with diffuse photon density wave methodology: pilot human study," Journal of Biomedical Optics 14(6), 064032 (1 November 2009). https://doi.org/10.1117/1.3275467
Published: 1 November 2009
JOURNAL ARTICLE
 10 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 37 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Wound healing
Diabetic foot ulcers
Tissue optics
Absorption
Diffuse photon density waves
Near infrared
Digital photography
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top