Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells

YongKeun Park; Monica Diez-Silva; Dan Fu; Gabriel Popescu; Wonshik Choi; Ishan Barman; Subra Suresh; Michael S. Feld

doi:10.1117/1.3369966

1 March 2010 Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells

YongKeun Park, Monica Diez-Silva, Dan Fu, Gabriel Popescu, Wonshik Choi, Ishan Barman, Subra Suresh, Michael S. Feld

Author Affiliations +

Journal of Biomedical Optics, Vol. 15, Issue 2, 020506 (March 2010). https://doi.org/10.1117/1.3369966

Abstract

We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

YongKeun Park, Monica Diez-Silva, Dan Fu, Gabriel Popescu, Wonshik Choi, Ishan Barman, Subra Suresh, and Michael S. Feld "Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells," Journal of Biomedical Optics 15(2), 020506 (1 March 2010). https://doi.org/10.1117/1.3369966

Published: 1 March 2010

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
3 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY