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1 July 2011 Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation
Matthew D. Keller, Elizabeth Vargis, Anita Mahadevan-Jansen, Nara de Matos Granja, Robert H. Wilson, Mary-Ann Mycek, Mark C. Kelley
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Journal of Biomedical Optics, Vol. 16, Issue 7, 077006 (July 2011). https://doi.org/10.1117/1.3600708
Abstract
The risk of local recurrence for breast cancers is strongly correlated with the presence of a tumor within 1 to 2 mm of the surgical margin on the excised specimen. Previous experimental and theoretical results suggest that spatially offset Raman spectroscopy (SORS) holds much promise for intraoperative margin analysis. Based on simulation predictions for signal-to-noise ratio differences among varying spatial offsets, a SORS probe with multiple source-detector offsets was designed and tested. It was then employed to acquire spectra from 35 frozen-thawed breast tissue samples invitro. Spectra from each detector ring were averaged to create a composite spectrum with biochemical information covering the entire range from the tissue surface to ∼2 mm below the surface, and a probabilistic classification scheme was used to classify these composite spectra as "negative" or "positive" margins. This discrimination was performed with 95% sensitivity and 100% specificity, or with 100% positive predictive value and 94% negative predictive value.
©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Matthew D. Keller, Elizabeth Vargis, Anita Mahadevan-Jansen, Nara de Matos Granja, Robert H. Wilson, Mary-Ann Mycek, and Mark C. Kelley "Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation," Journal of Biomedical Optics 16(7), 077006 (1 July 2011). https://doi.org/10.1117/1.3600708
Published: 1 July 2011
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Cited by 173 scholarly publications and 2 patents.
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KEYWORDS
Tumors
Tissues
Breast
Raman spectroscopy
Sensors
Signal to noise ratio
Natural surfaces
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