Multichannel near infrared spectroscopy indicates regional variations in cerebral autoregulation in infants supported on extracorporeal membrane oxygenation

Maria D. Papademetriou; Ilias Tachtsidis; Clare E. Elwell; Martin J. Elliot; Aparna Hoskote

doi:10.1117/1.JBO.17.6.067008

8 June 2012 Multichannel near infrared spectroscopy indicates regional variations in cerebral autoregulation in infants supported on extracorporeal membrane oxygenation

Maria D. Papademetriou, Ilias Tachtsidis, Clare E. Elwell, Martin J. Elliot, Aparna Hoskote

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Funded by: Wellcome Trust

Journal of Biomedical Optics, Vol. 17, Issue 6, 067008 (June 2012). https://doi.org/10.1117/1.JBO.17.6.067008

Abstract

Assessing noninvasively cerebral autoregulation, the protective mechanism of the brain to maintain constant cerebral blood flow despite changes in blood pressure, is challenging. Infants on life support system (ECMO) for cardiorespiratory failure are at risk of cerebral autoregulation impairment and consequent neurological problems. We measured oxyhaemoglobin concentration (HbO₂) by multichannel (12 channels) near-infrared spectroscopy (NIRS) in six infants during sequential changes in ECMO flow. Wavelet cross-correlation (WCC) between mean arterial pressure (MAP) and HbO₂ was used to construct a time-frequency representation of the concordance between the two signals to assess the nonstationary aspect of cerebral autoregulation and investigate regional variations. Group data showed that WCC increases with decreasing ECMO flow indicating higher concordance between MAP and HbO₂ and demonstrating loss of cerebral autoregulation at low ECMO flows. Statistically significant differences in WCC were observed between channels placed on the right and left scalp with channels on the right exhibiting higher values of WCC suggesting that the right hemisphere was more susceptible to disruption of cerebral autoregulation. Multichannel NIRS in conjunction with wavelet analysis methods can be used to assess regional variations in dynamic cerebral autoregulation with important clinical application in the management of critically ill children on life support systems.

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Maria D. Papademetriou, Ilias Tachtsidis, Clare E. Elwell, Martin J. Elliot, and Aparna Hoskote "Multichannel near infrared spectroscopy indicates regional variations in cerebral autoregulation in infants supported on extracorporeal membrane oxygenation," Journal of Biomedical Optics 17(6), 067008 (8 June 2012). https://doi.org/10.1117/1.JBO.17.6.067008

Published: 8 June 2012

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