Photoacoustic and ultrasound dual-modality imaging of human peripheral joints

Guan Xu; Justin R. Rajian; Gandikota Girish; Mariana J. Kaplan; J. Brian Fowlkes; Paul L. Carson; Xueding Wang

doi:10.1117/1.JBO.18.1.010502

12 December 2012 Photoacoustic and ultrasound dual-modality imaging of human peripheral joints

Guan Xu, Justin R. Rajian, Gandikota Girish, Mariana J. Kaplan, J. Brian Fowlkes, Paul L. Carson, Xueding Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 18, Issue 1, 010502 (December 2012). https://doi.org/10.1117/1.JBO.18.1.010502

Abstract

A photoacoustic (PA) and ultrasound (US) dual modality system, for imaging human peripheral joints, is introduced. The system utilizes a commercial US unit for both US control imaging and PA signal acquisition. Preliminary in vivo evaluation of the system, on normal volunteers, revealed that this system can recover both the structural and functional information of intra- and extra-articular tissues. Confirmed by the control US images, the system, on the PA mode, can differentiate tendon from surrounding soft tissue based on the endogenous optical contrast. Presenting both morphological and pathological information in joint, this system holds promise for diagnosis and characterization of inflammatory joint diseases such as rheumatoid arthritis.

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Guan Xu, Justin R. Rajian, Gandikota Girish, Mariana J. Kaplan, J. Brian Fowlkes, Paul L. Carson, and Xueding Wang "Photoacoustic and ultrasound dual-modality imaging of human peripheral joints," Journal of Biomedical Optics 18(1), 010502 (12 December 2012). https://doi.org/10.1117/1.JBO.18.1.010502

Published: 12 December 2012

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KEYWORDS

Imaging systems

Tissues

Ultrasonography

Acquisition tracking and pointing

Bone

Soft tissue optics

Tissue optics

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