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21 December 2016 Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography
Thu-Mai Nguyen, Ali Zorgani, Maxime Lescanne, Claude Boccara, Mathias Fink, Stefan Catheline
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Journal of Biomedical Optics, Vol. 21, Issue 12, 126013 (December 2016). https://doi.org/10.1117/1.JBO.21.12.126013
Abstract
Optical coherence tomography (OCT) can map the stiffness of biological tissue by imaging mechanical perturbations (shear waves) propagating in the tissue. Most shear wave elastography (SWE) techniques rely on active shear sources to generate controlled displacements that are tracked at ultrafast imaging rates. Here, we propose a noise-correlation approach to retrieve stiffness information from the imaging of diffuse displacement fields using low-frame rate spectral-domain OCT. We demonstrated the method on tissue-mimicking phantoms and validated the results by comparison with classic ultrafast SWE. Then we investigated the in vivo feasibility on the eye of an anesthetized rat by applying noise correlation to naturally occurring displacements. The results suggest a great potential for passive elastography based on the detection of natural pulsatile motions using conventional spectral-domain OCT systems. This would facilitate the transfer of OCT-elastography to clinical practice, in particular, in ophthalmology or dermatology.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2016/$25.00 © 2016 SPIE
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Thu-Mai Nguyen, Ali Zorgani, Maxime Lescanne, Claude Boccara, Mathias Fink, and Stefan Catheline "Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography," Journal of Biomedical Optics 21(12), 126013 (21 December 2016). https://doi.org/10.1117/1.JBO.21.12.126013
Received: 24 August 2016; Accepted: 1 December 2016; Published: 21 December 2016
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KEYWORDS
Tissues
Elastography
Optical coherence tomography
Eye
Wave propagation
Ultrafast imaging
In vivo imaging
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