Quantitative model of diffuse speckle contrast analysis for flow measurement

Jialin Liu; Hongchao Zhang; Jian Lu; Xiaowu Ni; Zhonghua Shen

doi:10.1117/1.JBO.22.7.076016

25 July 2017 Quantitative model of diffuse speckle contrast analysis for flow measurement

Jialin Liu, Hongchao Zhang, Jian Lu, Xiaowu Ni, Zhonghua Shen

Author Affiliations +

Journal of Biomedical Optics, Vol. 22, Issue 7, 076016 (July 2017). https://doi.org/10.1117/1.JBO.22.7.076016

Abstract

Diffuse speckle contrast analysis (DSCA) is a noninvasive optical technique capable of monitoring deep tissue blood flow. However, a detailed study of the speckle contrast model for DSCA has yet to be presented. We deduced the theoretical relationship between speckle contrast and exposure time and further simplified it to a linear approximation model. The feasibility of this linear model was validated by the liquid phantoms which demonstrated that the slope of this linear approximation was able to rapidly determine the Brownian diffusion coefficient of the turbid media at multiple distances using multiexposure speckle imaging. Furthermore, we have theoretically quantified the influence of optical property on the measurements of the Brownian diffusion coefficient which was a consequence of the fact that the slope of this linear approximation was demonstrated to be equal to the inverse of correlation time of the speckle.

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Jialin Liu, Hongchao Zhang, Jian Lu, Xiaowu Ni, and Zhonghua Shen "Quantitative model of diffuse speckle contrast analysis for flow measurement," Journal of Biomedical Optics 22(7), 076016 (25 July 2017). https://doi.org/10.1117/1.JBO.22.7.076016

Received: 19 April 2017; Accepted: 30 June 2017; Published: 25 July 2017

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