Smartphone snapshot mapping of skin chromophores under triple-wavelength laser illumination

Janis Spigulis; Ilze Oshina; Anna Berzina; Alexander Bykov

doi:10.1117/1.JBO.22.9.091508

2 March 2017 Smartphone snapshot mapping of skin chromophores under triple-wavelength laser illumination

Janis Spigulis, Ilze Oshina, Anna Berzina, Alexander Bykov

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Journal of Biomedical Optics, Vol. 22, Issue 9, 091508 (March 2017). https://doi.org/10.1117/1.JBO.22.9.091508

Abstract

Chromophore distribution maps are useful tools for skin malformation severity assessment and for monitoring of skin recovery after burns, surgeries, and other interactions. The chromophore maps can be obtained by processing several spectral images of skin, e.g., captured by hyperspectral or multispectral cameras during seconds or even minutes. To avoid motion artifacts and simplify the procedure, a single-snapshot technique for mapping melanin, oxyhemoglobin, and deoxyhemoglobin of in-vivo skin by a smartphone under simultaneous three-wavelength (448–532–659 nm) laser illumination is proposed and examined. Three monochromatic spectral images related to the illumination wavelengths were extracted from the smartphone camera RGB image data set with respect to crosstalk between the RGB detection bands. Spectral images were further processed accordingly to Beer’s law in a three chromophore approximation. Photon absorption path lengths in skin at the exploited wavelengths were estimated by means of Monte Carlo simulations. The technique was validated clinically on three kinds of skin lesions: nevi, hemangiomas, and seborrheic keratosis. Design of the developed add-on laser illumination system, image-processing details, and the results of clinical measurements are presented and discussed.

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Janis Spigulis, Ilze Oshina, Anna Berzina, and Alexander Bykov "Smartphone snapshot mapping of skin chromophores under triple-wavelength laser illumination," Journal of Biomedical Optics 22(9), 091508 (2 March 2017). https://doi.org/10.1117/1.JBO.22.9.091508

Received: 30 November 2016; Accepted: 10 February 2017; Published: 2 March 2017

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