Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during in vivo laser ablations of biological tissue

Paola Saccomandi; Ambra Varalda; Riccardo Gassino; Daniele Tosi; Carlo Massaroni; Michele A. Caponero; Raoul Pop; Sanzhar Korganbayev; Guido Perrone; Michele Diana; Alberto Vallan; Guido Costamagna; Jacques Marescaux; Emiliano Schena

doi:10.1117/1.JBO.22.9.097002

14 September 2017 Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during in vivo laser ablations of biological tissue

Paola Saccomandi, Ambra Varalda, Riccardo Gassino, Daniele Tosi, Carlo Massaroni, Michele A. Caponero, Raoul Pop, Sanzhar Korganbayev, Guido Perrone, Michele Diana, Alberto Vallan, Guido Costamagna, Jacques Marescaux, Emiliano Schena

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Journal of Biomedical Optics, Vol. 22, Issue 9, 097002 (September 2017). https://doi.org/10.1117/1.JBO.22.9.097002

Abstract

The response of a fiber optic sensor [linearly chirped fiber Bragg grating (LCFBG)] to a linear thermal gradient applied on its sensing length (i.e., 1.5 cm) has been investigated. After these bench tests, we assessed their feasibility for temperature monitoring during thermal tumor treatment. In particular, we performed experiments during ex vivo laser ablation (LA) in pig liver and in vivo thermal ablation in animal models (pigs). We investigated the following: (i) the relationship between the full width at half maximum of the LCFBG spectrum and the temperature difference among the extremities of the LCFBG and (ii) the relationship between the mean spectrum wavelength and the mean temperature acting on the LCFBG sensing area. These relationships showed a linear trend during both bench tests and LA in animal models. Thermal sensitivity was significant although different values were found with regards to bench tests and animal experiments. The linear trend and significant sensitivity allow hypothesizing a future use of this kind of sensor to monitor both temperature gradient and mean temperature within a tissue undergoing thermal treatment.

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Paola Saccomandi, Ambra Varalda, Riccardo Gassino, Daniele Tosi, Carlo Massaroni, Michele A. Caponero, Raoul Pop, Sanzhar Korganbayev, Guido Perrone, Michele Diana, Alberto Vallan, Guido Costamagna, Jacques Marescaux, and Emiliano Schena "Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during in vivo laser ablations of biological tissue," Journal of Biomedical Optics 22(9), 097002 (14 September 2017). https://doi.org/10.1117/1.JBO.22.9.097002

Received: 18 May 2017; Accepted: 17 August 2017; Published: 14 September 2017

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