Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis

Nils Petitdidier; Anne Koenig; Rémi Gerbelot; Henri Grateau; Sylvain Gioux; Pierre Jallon

doi:10.1117/1.JBO.23.11.115003

13 November 2018 Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis

Nils Petitdidier, Anne Koenig, Rémi Gerbelot, Henri Grateau, Sylvain Gioux, Pierre Jallon

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Journal of Biomedical Optics, Vol. 23, Issue 11, 115003 (November 2018). https://doi.org/10.1117/1.JBO.23.11.115003

Abstract

Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, current fiber-based and photodiode-based systems have difficulties achieving this goal due to challenges in sampling the reflectance with a high enough resolution. We introduce a compact, low-cost architecture for srDRS based on the use of a multipixel imaging sensor and light-emitting diodes to achieve lensless diffuse reflectance imaging in contact with the tissue with high spatial resolution. For proof-of-concept, a prototype device, involving a commercially available complementary metal–oxide semiconductor coupled with a fiber-optic plate, was fabricated. Diffuse reflectance profiles were acquired at 645 nm at source-to-detector separations ranging from 480 μm to 4 mm with a resolution of 16.7 μm. Absorption coefficients (μ_a) and reduced scattering coefficients ( μs′) of homogeneous tissue-mimicking phantoms were measured with 4.2 ± 3.5 % and 7.0 ± 4.6 % error, respectively. The results obtained confirm the potential of our approach for quantitative characterization of tissue optical properties in contact imaging modality. This study is a first step toward the development of low-cost, wearable devices for skin condition diagnosis in vivo.

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Nils Petitdidier, Anne Koenig, Rémi Gerbelot, Henri Grateau, Sylvain Gioux, and Pierre Jallon "Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis," Journal of Biomedical Optics 23(11), 115003 (13 November 2018). https://doi.org/10.1117/1.JBO.23.11.115003

Received: 31 May 2018; Accepted: 15 October 2018; Published: 13 November 2018

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Cited by 6 scholarly publications and 2 patents.

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KEYWORDS

Diffuse reflectance spectroscopy

Scattering

Tissue optics

Absorption

Reflectivity

Skin

Imaging systems

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