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9 January 2020 Subdiffuse scattering model for single fiber reflectance spectroscopy
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Abstract

To detect small-scale changes in tissue with optical techniques, small sampling volumes are required. Single fiber reflectance (SFR) spectroscopy has a sampling depth of a few hundred micrometers. SFR spectroscopy uses a single fiber to emit and collect light. The only available model to determine optical properties with SFR spectroscopy was derived for tissues with modified Henyey–Greenstein phase functions. Previously, we demonstrated that this model is inadequate for other tissue phase functions. We develop a model to relate SFR measurements to scattering properties for a range of phase functions, in the absence of absorption. Since the source and detector overlap, the reflectance cannot be accurately described by diffusion theory alone: SFR measurements are subdiffuse. Therefore, we describe the reflectance as a combination of a diffuse and a semiballistic component. We use the model of Farrell et al. for the diffuse component, solved for an overlapping source and detector fiber. For the semiballistic component, we derive a new parameter, psb, which incorporates the integrals of the phase function over 1 deg in the backward direction and 23 deg in the forward direction. Our model predicts the reflectance with a median error of 2.1%, compared to 9.0% for the currently available model.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Anouk L. Post, Henricus J. C. M. Sterenborg, Fransien G. Woltjer, Ton G. van Leeuwen, and Dirk J. Faber "Subdiffuse scattering model for single fiber reflectance spectroscopy," Journal of Biomedical Optics 25(1), 015001 (9 January 2020). https://doi.org/10.1117/1.JBO.25.1.015001
Received: 24 September 2019; Accepted: 3 December 2019; Published: 9 January 2020
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CITATIONS
Cited by 10 scholarly publications.
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KEYWORDS
Reflectivity

Scattering

Photons

Tissues

Reflectance spectroscopy

Monte Carlo methods

Tissue optics

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