Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images

Erica L. Heffer; Vivian E. Pera; Oliver Schütz; Horst Siebold; Sergio Fantini

doi:10.1117/1.1805552

1 November 2004 Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images

Erica L. Heffer, Vivian E. Pera, Oliver Schütz, Horst Siebold, Sergio Fantini

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Journal of Biomedical Optics, Vol. 9, Issue 6, (November 2004). https://doi.org/10.1117/1.1805552

Abstract

We have previously reported a comparison between edge-corrected near-infrared optical mammograms and those that have undergone a further image-processing step based on a spatial second derivative. In this work, we go a step further by combining the second-derivative images from four wavelengths (690, 750, 788, and 856 nm) to obtain oxygenation-index images. While the spatial second derivative improves contrast and allows for visibility of fine structures in the images, thereby improving the sensitivity to tumor detection, additional information is needed to avoid false-positive results. The oxygenation-index images are introduced to address this issue. Oxygenation information may help discriminate benign from malignant breast lesions, thereby effectively complementing single-wavelength optical mammograms that display optically dense regions within the breast with high sensitivity.

©(2004) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Erica L. Heffer, Vivian E. Pera, Oliver Schütz, Horst Siebold, and Sergio Fantini "Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images," Journal of Biomedical Optics 9(6), (1 November 2004). https://doi.org/10.1117/1.1805552

Published: 1 November 2004

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