1 August 2024 Left ventricular structural integrity on tetralogy of Fallot patients: approach using longitudinal relaxation time mapping
Giorgos Broumpoulis, Efstratios Karavasilis, Niki Lama, Ioannis Papadopoulos, Panagiotis Zachos, Sotiria Apostolopoulou, Nikolaos Kelekis
Author Affiliations +
Abstract

Purpose

Tetralogy of Fallot (TOF) is a congenital heart disease, and patients undergo surgical repair early in their lives. The evaluation of TOF patients is continuous through their adulthood. The use of cardiac magnetic resonance imaging (CMR) is vital for the evaluation of TOF patients. We aim to correlate advanced MRI sequences [parametric longitudinal relaxation time (T1), extracellular volume (ECV) mapping] with cardiac functionality to provide biomarkers for the evaluation of these patients.

Methods

A complete CMR examination with the same imaging protocol was conducted in a total of 11 TOF patients and a control group of 25 healthy individuals. A Modified Look-Locker Inversion recovery (MOLLI) sequence was included to acquire the global T1 myocardial relaxation times of the left ventricular (LV) pre and post-contrast administration. Appropriate software (Circle cmr42) was used for the CMR analysis and the calculation of native, post-contrast T1, and ECV maps. A regression analysis was conducted for the correlation between global LV T1 values and right ventricular (RV) functional indices.

Results

Statistically significant results were obtained for RV cardiac index [RV_CI= −32.765 + 0.029 × T1 native; p=0.003], RV end diastolic volume [RV_EDV/BSA = −1023.872 + 0.902 × T1 native; p=0.001], and RV end systolic volume [RV_ESV/BSA = −536.704 + 0.472 × T1 native; p=0.011].

Conclusions

We further support the diagnostic importance of T1 mapping as a structural imaging tool in CMR. In addition to the well-known affected RV function in TOF patients, the LV structure is also impaired as there is a strong correlation between LV T1 mapping and RV function, evoking that the heart operates as an entity.

© 2024 Society of Photo-Optical Instrumentation Engineers (SPIE)
Giorgos Broumpoulis, Efstratios Karavasilis, Niki Lama, Ioannis Papadopoulos, Panagiotis Zachos, Sotiria Apostolopoulou, and Nikolaos Kelekis "Left ventricular structural integrity on tetralogy of Fallot patients: approach using longitudinal relaxation time mapping," Journal of Medical Imaging 11(4), 044004 (1 August 2024). https://doi.org/10.1117/1.JMI.11.4.044004
Received: 15 January 2024; Accepted: 9 July 2024; Published: 1 August 2024
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Cardiovascular magnetic resonance imaging

Heart

Magnetic resonance imaging

Gadolinium

Cardiovascular disorders

Statistical analysis

Arteries

Back to Top