Label-free clinical metabolic and biochemical imaging of the oral epithelial cancer enabled by autofluorescence lifetime imaging endoscopy

Rodrigo Cuenca Martinez; Michael J. Serafino; Gabriel P. Tortorelli; Sharukh S. Khajotia; Ronald C. Faram; David M. Lewis; Lida Radfar; Kathleen E. Higgins; Yi-Shing L. Cheng; Javier A. Jo

doi:10.1117/12.2609017

7 March 2022 Label-free clinical metabolic and biochemical imaging of the oral epithelial cancer enabled by autofluorescence lifetime imaging endoscopy

Rodrigo Cuenca Martinez, Michael J. Serafino, Gabriel P. Tortorelli, Sharukh S. Khajotia, Ronald C. Faram, David M. Lewis, Lida Radfar, Kathleen E. Higgins, Yi-Shing L. Cheng, Javier A. Jo

Author Affiliations +

Proceedings Volume PC11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022; PC1193509 (2022) https://doi.org/10.1117/12.2609017
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Increased cellular metabolic activity can be quantified by imaging the oral tissue autofluorescence originated from NADH and FAD. Clinical label-free metabolic imaging of oral epithelial cancer based on 375-nm excitation maFLIM endoscopy was recently demonstrated in patients presenting oral malignant lesions. A recently upgraded maFLIM endoscopy system enables simultaneous autofluorescence excitation at 375 nm (for NADH) and 445 nm (for FAD). This maFLIM endoscope is being used to clinically image healthy, benign, precancerous and cancerous oral lesions in oral health care settings. Comprehensive statistical analysis will be performed to identify new metabolic and biochemical autofluorescence biomarkers of oral epithelial cancer.

Conference Presentation

Citation Download Citation

Rodrigo Cuenca Martinez, Michael J. Serafino, Gabriel P. Tortorelli, Sharukh S. Khajotia, Ronald C. Faram, David M. Lewis, Lida Radfar, Kathleen E. Higgins, Yi-Shing L. Cheng, and Javier A. Jo "Label-free clinical metabolic and biochemical imaging of the oral epithelial cancer enabled by autofluorescence lifetime imaging endoscopy", Proc. SPIE PC11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022, PC1193509 (7 March 2022); https://doi.org/10.1117/12.2609017

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available