In vitro terahertz spectroscopy of gelatin-embedded human brain tumors: a pilot study

N. V. Chernomyrdin; A. A. Gavdush; S.-I. T. Beshplav; K. M. Malakhov; A. S. Kucheryavenko; G. M. Katyba; I. N. Dolganova; S. A. Goryaynov; V. E. Karasik; I. E. Spektor; V. N. Kurlov; S. O. Yurchenko; G. A. Komandin; A. A. Potapov; V. V. Tuchin; K. I. Zaytsev

doi:10.1117/12.2316302

26 April 2018 In vitro terahertz spectroscopy of gelatin-embedded human brain tumors: a pilot study

N. V. Chernomyrdin, A. A. Gavdush, S.-I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, K. I. Zaytsev

Author Affiliations +

Proceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX; 107160S (2018) https://doi.org/10.1117/12.2316302
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

We have performed the in vitro terahertz (THz) spectroscopy of human brain tumors. In order to fix tissues for the THz measurements, we have applied the gelatin embedding. It allows for preserving tissues from hydration/dehydration and sustaining their THz response similar to that of the freshly-excised tissues for a long time after resection. We have assembled an experimental setup for the reflection-mode measurements of human brain tissues based on the THz pulsed spectrometer. We have used this setup to study in vitro the refractive index and the amplitude absorption coefficient of 2 samples of malignant glioma (grade IV), 1 sample of meningioma (grade I), and samples of intact tissues. We have observed significant differences between the THz responses of normal and pathological tissues of the brain. The results of this paper highlight the potential of the THz technology in the intraoperative neurodiagnosis of tumors relying on the endogenous labels of tumorous tissues.

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N. V. Chernomyrdin, A. A. Gavdush, S.-I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev "In vitro terahertz spectroscopy of gelatin-embedded human brain tumors: a pilot study", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160S (26 April 2018); https://doi.org/10.1117/12.2316302

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