Development and validation of a method for 11-nor-9-carboxy-delta9-tetrahydrocannabinol quantification using gas chromatography coupled to triple quadrupole mass spectrometry

Alice Pop; George Dănilă; Mirela Zorio; Valentin Pop

doi:10.1117/12.2323595

31 December 2018 Development and validation of a method for 11-nor-9-carboxy-delta9-tetrahydrocannabinol quantification using gas chromatography coupled to triple quadrupole mass spectrometry

Alice Pop, George Dănilă, Mirela Zorio, Valentin Pop

Author Affiliations +

Proceedings Volume 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX; 1097714 (2018) https://doi.org/10.1117/12.2323595
Event: Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies IX, 2018, Constanta, Romania

Abstract

This paper presents a method for 11-nor-9-carboxy-delta9-tetrahydrocanabinol (THC-COOH) quantification from urine samples, for doping control purposes. The method involves gas chromatography coupled to triple quadrupole mass spectrometry (GC-MS/MS). Considering the complexity of the urine matrix, this technique allows for an improved selectivity, compared to the previously used gas chromatography – single quadrupole mass spectrometry (GC-MS) method. World Anti-Doping Agency (WADA) Technical Documents are imposing a threshold of 150ng/mL, a maximum combined standard uncertainty at threshold of 10% and calibration range between 50%-200% of the threshold. The method developed has been proved to be fit for purpose, with a combined standard uncertainty at the threshold of 7.61%.

Citation Download Citation

Alice Pop, George Dănilă, Mirela Zorio, and Valentin Pop "Development and validation of a method for 11-nor-9-carboxy-delta9-tetrahydrocannabinol quantification using gas chromatography coupled to triple quadrupole mass spectrometry", Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 1097714 (31 December 2018); https://doi.org/10.1117/12.2323595

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KEYWORDS

Calibration

Chromatography

Mass spectrometry

Doping

Potassium

Statistical analysis

Carbon monoxide

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