Engineering of fluorescent biomaging tools for cancer cell targeting based on polyelectrolyte microcapsules encoded with quantum dots

Galina Nifontova; Maria Baryshnikova; Fernanda Ramos-Gomes; Frauke Alves; Igor Nabiev; Alyona Sukhanova

doi:10.1117/12.2530281

3 October 2019 Engineering of fluorescent biomaging tools for cancer cell targeting based on polyelectrolyte microcapsules encoded with quantum dots

Galina Nifontova, Maria Baryshnikova, Fernanda Ramos-Gomes, Frauke Alves, Igor Nabiev, Alyona Sukhanova

Author Affiliations +

Proceedings Volume 11207, Fourth International Conference on Applications of Optics and Photonics; 112072D (2019) https://doi.org/10.1117/12.2530281
Event: IV International Conference on Applications of Optics and Photonics (AOP 2019), 2019, Lisbon, Portugal

Abstract

Quantum dots (QDs) are fluorescent semiconductor nanocrystals with a high photostability, wide absorption spectra, and narrow, size-tunable emission spectra, which make them promising nanolabels to be encapsulated in microcarriers used as bioimaging and theranostic tools. Here, we describe an approach to the optical encoding of polyelectrolyte microcapsules with the prepared stable water-soluble QDs and key stages of surface functionalization of these microcapsules with cetuximab, humanised monoclonal anticancer antibody. Obtained conjugates demonstrate the specificity and efficiency of the engineered system as a cancer cell–targeted tracing tool that could be used for cancer diagnosis, treatment and monitoring of cancer therapy.

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Galina Nifontova, Maria Baryshnikova, Fernanda Ramos-Gomes, Frauke Alves, Igor Nabiev, and Alyona Sukhanova "Engineering of fluorescent biomaging tools for cancer cell targeting based on polyelectrolyte microcapsules encoded with quantum dots", Proc. SPIE 11207, Fourth International Conference on Applications of Optics and Photonics, 112072D (3 October 2019); https://doi.org/10.1117/12.2530281

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