Ultrafast optical resolution photoacoustic microscopy in vivo

Jian Zeng; Weizhi Qi; Tian Jin; Lei Xi

doi:10.1117/12.2548903

20 December 2019 Ultrafast optical resolution photoacoustic microscopy in vivo

Jian Zeng, Weizhi Qi, Tian Jin, Lei Xi

Proceedings Volume 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019); 112093L (2019) https://doi.org/10.1117/12.2548903
Event: Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 2019, Xi'an, China

Abstract

Photoacoustic Imaging (PAI) is an emerging non-ionizing and non-invasive biomedical imaging method in the past few years. PAI can effectively obtain both structural and functional information of bio-tissues, providing an important method for studying the morphological structure and physiological characteristics of bio-tissues, especially suitable for early-stage cancer diagnosis. As one important subtype of PAI, optical resolution photoacoustic microscopy (ORPAM) has the advantages of high spatial resolution and imaging contrast. ORPAM has been proved to be an effective and powerful method in hemodynamic and micro-circulation studies. However, due to the low scanning speed over a large field of view (FOV), the application of existing ORPAM systems has been greatly limited. In order to overcome these limitations, we report an ultrafast ORPAM (U-ORPAM) system in this research. By combining our novel rotary scanning protocol with a 200 kHz ultrafast pulsed laser, U-ORPAM has the ability to image an 8-mm-diameter FOV in 5 seconds. Both phantom and in vivo experiments were carried out to demonstrate the performance of the image system. These results indicate that U-ORPAM has equivalent imaging qualities with other ORPAM systems with a much higher imaging speed. These advantages make U-ORPAM a promising tool for the investigation of rapid hemodynamic research and clinical biomedical research.

Citation Download Citation

Jian Zeng, Weizhi Qi, Tian Jin, and Lei Xi "Ultrafast optical resolution photoacoustic microscopy in vivo", Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 112093L (20 December 2019); https://doi.org/10.1117/12.2548903

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KEYWORDS

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Imaging systems

In vivo imaging

Brain

Neuroimaging

Medical research

Optical resolution

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