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10 March 2020 Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)
Fabio Feroldi, Margherita Vaselli, Mariska Verlaan, Helene Knaus, Valentina Davidoiu, Danielle Vugts, Carla Molthoff, Guus van Dongen, Johannes F. de Boer
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Proceedings Volume 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI; 1122204 (2020) https://doi.org/10.1117/12.2545222
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Imaging the heterogeneity of the tumor microenvironment is thought to be valuable for assessing the efficacy of a cancer therapy. However, due to the insufficient resolution of clinically available molecular imaging tools such as positron emission tomography, this feat is currently not achievable. Here, we demonstrate that revealing the TME is possible with immuno-near-infrared-fluorescence (Immuno-NIRF) imaging. Moreover, we combined immuno-NIRF with optical coherence tomography (OCT) to provide structural context to the molecular images. The combination of the two techniques may represent a novel tool in the operating room for assessing development or early diagnosis of tumors.
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Fabio Feroldi, Margherita Vaselli, Mariska Verlaan, Helene Knaus, Valentina Davidoiu, Danielle Vugts, Carla Molthoff, Guus van Dongen, and Johannes F. de Boer "Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)", Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 1122204 (10 March 2020); https://doi.org/10.1117/12.2545222
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KEYWORDS
Optical coherence tomography
Tumors
Molecular imaging
Image resolution
Positron emission tomography
Endoscopy
Mouse models
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