Stain-free optical biomarkers for bladder cancer tissues based on interferometric phase microscopy (Conference Presentation)

Natan T. Shaked; Miki Haifler; Ofer Goldstein; Almog Yogev

doi:10.1117/12.2555315

2 April 2020 Stain-free optical biomarkers for bladder cancer tissues based on interferometric phase microscopy (Conference Presentation)

Natan T. Shaked, Miki Haifler, Ofer Goldstein, Almog Yogev

Author Affiliations +

Proceedings Volume 11363, Tissue Optics and Photonics; 113630H (2020) https://doi.org/10.1117/12.2555315
Event: SPIE Photonics Europe, 2020, Online Only

Abstract

We developed stain-free optical biomarkers for high-grade T1 bladder cancer tissues based on interferometric phase microscopy (IPM). IPM records a topographic map that represents, for each spatial point, the integral of the refractive-index values along the tissue sample thickness, thus accounting for both the tissue internal morphology and contents. Following the extraction of various parameters from this IPM-based topographic maps of healthy and bladder cancer tissues, we employed a machine learning multivariant analysis for stain-free grading of the bladder cancer invasiveness. Our tools are expected to be used for rapid and inexpensive diagnosis of bladder cancer tissues.

Conference Presentation

Citation Download Citation

Natan T. Shaked, Miki Haifler, Ofer Goldstein, and Almog Yogev "Stain-free optical biomarkers for bladder cancer tissues based on interferometric phase microscopy (Conference Presentation)", Proc. SPIE 11363, Tissue Optics and Photonics, 113630H (2 April 2020); https://doi.org/10.1117/12.2555315

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