Prof. Natan T. Shaked Profile

Prof. Natan T. Shaked

Full Professor at Tel Aviv Univ

SPIE Involvement:

Conference Chair | Conference Program Committee | Editor | Author

Area of Expertise:

Biomedical microscopy and nanoscopy , Interferometric microscopy , Cell imaging , Holography , Nanoparticles

Websites:

Personal Website

Profile Summary

Natan T. Shaked is a Full Professor in the Department of Biomedical Engineering at Tel Aviv University, Israel. He heads a large multidisciplinary group dealing with biomedical optical interferometric microscopy and nanoscopy. Prof. Shaked is the author of more than 80 refereed journal papers and 150 conference papers. He also serves as the chair of the Label-Free Biomedical Imaging and Sensing (LBIS) Conference in SPIE Photonics West. He is an SPIE Fellow and an OSA Fellow.

Publications (70)

Proceedings Article | 12 August 2023 Presentation

Presentation

Label-free white blood cell classification during flow combining holographic imaging with deep learning

Anat Cohen, Matan Dudaie, Itay Barnea, Natan Shaked

Proceedings Volume PC12622, PC126220L (2023) https://doi.org/10.1117/12.2670572

KEYWORDS: White blood cells, Neurological disorders, Holography, Deep learning, Blood, Surface chemistry, Pathophysiology, Optical path differences, Holograms, Feature extraction

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Proceedings Article | 12 August 2023 Presentation

Presentation

Quantitative imaging flow cytometry based on digital holographic microscopy

Natan Shaked

Proceedings Volume PC12622, PC126220H (2023) https://doi.org/10.1117/12.2674432

KEYWORDS: Digital holography, Flow cytometry, Microscopy, Holography, Holographic interferometry, Phase interferometry, Optical path differences, Image analysis, Fluorescence microscopy, Wavefronts

Read Abstract +

I will review our latest results in the field of quantitative imaging flow cytometry using off-axis holography. Flow cytometry has a great diagnosis potential, due to its ability to analyze a large number of cells during flow for samples obtained from body fluids. Since cellular morphology analysis plays an important role in various clinical diagnoses, such as screening cancer and various chronic diseases, flow cytometry is much anticipated to incorporate imaging capabilities, providing a more comprehensive analysis by presenting a detailed morphological structure image of individual cells. In addition, some erroneous analysis results, yielded in conventional flow cytometry, can be eliminated by acquiring and analyzing such cell images by clearly distinguishing between cells, debris, and clusters of cells. While conventional flow cytometry measures the integral intensity of fluorescent emission, fluorescence microscopy is able to yield the exact morphology of the cell and its organelles. Recent advances in imaging technologies, as well as the exponentially evolving computational capacity, have enabled imaging flow cytometry (IFC) by integrating fluorescence microscopy and conventional flow cytometry. However, the current-generation IFC remains highly inaccessible technology, due to its cost, requirement for operator expertise, lack of accuracy, and lack of objectiveness of data produced. We developed new approach for IFC, which is based on stain-free interferometric phase microscopy, a digital holographic microscopy technique. Using an external interferometric module and cutting-edge deep-learning analysis methods, we generate virtually stained cell images of a volume of cells, with a clear morphological discrimination between various cellular organelles. The module acquires, in a single camera frame, the digital hologram of the cell during flow, and our rapid reconstruction algorithms retrieve the complex wavefront of the cell, from which the optical path delay (OPD) topological map is calculated. This map represents, on each spatial point, the product of the cell physical thickness and its refractive index, accounting for both the cell morphology and contents. Such map is subsequently used as the input to a deep convolutional neural network that is pre-trained to transform the cell OPD into a 2-D image with stained-like organelles. The same IFC setup is also used for automatic cell classification. We demonstrate using the system for cancer detection in liquid biopsies.

Proceedings Article | 16 March 2023 Presentation

Presentation

Label-free cytometry for the classification and diagnosis of bladder cancer (Conference Presentation)

Matan Dudaie, Miki Haifler, Natan Shaked, Itay Barnea

Proceedings Volume PC12391, PC123910G (2023) https://doi.org/10.1117/12.2651370

KEYWORDS: Bladder cancer, Cystoscopy, Tumors, Cancer, Statistical analysis, Relativity, Optical testing, Optical microscopy, Holograms, Feature extraction

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Proceedings Article | 16 March 2023 Presentation

Presentation

Combining holography and Raman spectroscopy for cancer-tissue evaluation (Conference Presentation)

Omri Plotnik, Almog Taieb, Garry Berkovic, Miki Haifler, Ori Chehnovsky, Natan Shaked

Proceedings Volume PC12391, PC123910H (2023) https://doi.org/10.1117/12.2651378

KEYWORDS: Raman spectroscopy, Holography, Tissue optics, Tissues, Phase imaging, Digital holography, Chemical analysis, Cancer, Wavefronts, Visualization

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Proceedings Article | 16 March 2023 Presentation

Presentation

Deep2Deep: AI and deep learning for label-free 3D cell classification (Conference Presentation)

Natan Shaked

Proceedings Volume PC12391, PC123910L (2023) https://doi.org/10.1117/12.2674091

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Proceedings Article | 3 October 2022 Presentation

Presentation

Sperm-cell DNA fragmentation prediction using label-free quantitative phase imaging and deep learning (Conference Presentation)

Lioz Noy, Itay Barnea, Simcha Mirsky, Dotan Kambar, Mattan Levi, Natan Tzvi Shaked

Proceedings Volume 12226, 122260W (2022) https://doi.org/10.1117/12.2635449

KEYWORDS: Adaptive optics, Phase contrast, Machine vision, Interferometry, In vitro testing, Image processing, Digital image correlation, Computer vision technology

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Proceedings Article | 2 March 2022 Presentation

Presentation

Dynamic tomography by six-pack holography

Simcha Mirsky, Natan Shaked

Proceedings Volume PC11972, PC119720V (2022) https://doi.org/10.1117/12.2608135

KEYWORDS: Tomography, Holography, Optical tomography, Holograms, Cameras, Video, Refractive index, Reconstruction algorithms, Image resolution, Flow cytometry

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Proceedings Article | 2 March 2022 Presentation

Presentation

Real-time 3D quantitative sperm-cell imaging: new horizons for in-vitro fertilization

Natan Shaked

Proceedings Volume PC11970, PC119700D (2022) https://doi.org/10.1117/12.2607768

KEYWORDS: Stereoscopy, In vitro testing, 3D image processing, Head, Tomography, Holograms, Spatial resolution, Reconstruction algorithms, Phase imaging, Optical tomography

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Proceedings Article | 20 June 2021 Presentation

Presentation

Microfluidics imaging for label-free metrology of individual biological cells

Yuval Atzitz, Itay Barnea, Natan Shaked

Proceedings Volume 11786, 117860E (2021) https://doi.org/10.1117/12.2593398

KEYWORDS: Metrology, Microfluidic imaging, Biological research, Microfluidics, Interferometry

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Proceedings Article | 20 June 2021 Presentation

Presentation

Quantitative analysis of malignant and normal bladder tissue based on combination of interferometric phase microscopy and Raman spectroscopy

Almog Taieb, Garry Berkovic, Miki Haifler, Natan Shaked

Proceedings Volume 11786, 1178618 (2021) https://doi.org/10.1117/12.2593397

KEYWORDS: Tissues, Raman spectroscopy, Tissue optics, Phase interferometry, Microscopy, Interferometry, Bladder, Quantitative analysis, Remote sensing, Cancer

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Proceedings Article | 20 June 2021 Presentation

Presentation

Stain-free 4D imaging of live sperm cells: the future of in-vitro fertilization

Natan Shaked

Proceedings Volume 11786, 1178615 (2021) https://doi.org/10.1117/12.2593193

KEYWORDS: In vitro testing, 3D acquisition, Head

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Proceedings Article | 5 March 2021 Presentation

Presentation

Quantitative phase imaging by a shearing interferometric module with constant off-axis angle (SICA) module

Rongli Guo, Itay Barnea, Simcha K. Mirsky, Matan Dudaie, Natan Shaked

Proceedings Volume 11655, 116550X (2021) https://doi.org/10.1117/12.2581756

KEYWORDS: Interferometry, Phase imaging, Microscopes, Light sources, Spatial filters, Shearing interferometers, Phase interferometry, Imaging systems, Holography, Holographic interferometry

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Proceedings Article | 5 March 2021 Presentation

Presentation

Six-pack holographic imaging for dynamic rejection of out-of-focus objects

Simcha Mirsky, Natan Shaked

Proceedings Volume 11655, 116550Y (2021) https://doi.org/10.1117/12.2582691

KEYWORDS: Holography, Video, Spherical lenses, Holograms, Cameras, 3D image reconstruction

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Proceedings Article | 5 March 2021 Presentation

Presentation

Welcome and Introduction to SPIE Conference 11655

Natan Shaked, Oliver Hayden

Proceedings Volume 11655, 1165502 (2021) https://doi.org/10.1117/12.2595084

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Proceedings Article | 5 March 2021 Presentation

Presentation

Label-free 3D refractive index interferometric tomography of live cells with full angular coverage

Matan Dudaie, Itay Barnea, Natan Shaked

Proceedings Volume 11655, 116550W (2021) https://doi.org/10.1117/12.2578229

KEYWORDS: Tomography, Refractive index, Interferometry, Cancer, Imaging systems, Capillaries, 3D image processing, Visualization, Spatial frequencies, Optical microscopy

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Proceedings Article | 5 March 2021 Presentation

Presentation

Hybridization of quantitative phase microscopy and fluorescent microscopy in measurements of cells under osmotic stress

Almog Taieb, Itay Barnea, Natan Tzvi Shaked

Proceedings Volume 11655, 116550U (2021) https://doi.org/10.1117/12.2577827

KEYWORDS: Microscopy, Multimodal imaging, Interferometry, Phase interferometry, Microscopes, Luminescence, Live cell imaging, Holograms, Green fluorescent protein

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Proceedings Article | 5 March 2021 Presentation

Presentation

High throughput droplet microfluidics for label-free analysis of individual cells

Yuval Atzitz, Itay Barnea, Natan Tzvi Shaked

Proceedings Volume 11655, 116550V (2021) https://doi.org/10.1117/12.2578171

KEYWORDS: Microfluidics, Holograms

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Proceedings Article | 15 February 2021 Poster + Presentation + Paper

Poster + Presentation + Paper

Deep learning analysis on raw image data: case study on holographic cell analysis

Gal Gozes, Shani Ben Baruch, Noa Rotman-Nativ, Darina Roitshtain, Natan Shaked, Hayit Greenspan

Proceedings Volume 11597, 1159723 (2021) https://doi.org/10.1117/12.2582101

KEYWORDS: Image analysis, Holography, Holograms, Systems modeling, Image processing, Data modeling, Mathematical modeling, Image classification, Image acquisition, Complex systems

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Proceedings Article | 22 April 2020 Presentation

Presentation

Denoising holograms using unsupervised learning (Conference Presentation)

Keren Ben-Yehuda, Natan Shaked

Proceedings Volume 11402, 114020I (2020) https://doi.org/10.1117/12.2559650

KEYWORDS: Holograms, Denoising, Machine learning, Holographic interferometry, Interferometry, Phase interferometry, Microscopy, Refractive index, In vitro testing

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Proceedings Article | 2 April 2020 Presentation

Presentation

Stain-free optical biomarkers for bladder cancer tissues based on interferometric phase microscopy (Conference Presentation)

Natan Shaked, Miki Haifler, Ofer Goldstein, Almog Yogev

Proceedings Volume 11363, 113630H (2020) https://doi.org/10.1117/12.2555315

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Proceedings Article | 10 March 2020 Presentation

Presentation

Label free discrimination and selection of cancer cells during flow (Conference Presentation)

Matan Dudaie, Noga Nissim, Itay Barnea, Natan Shaked

Proceedings Volume 11251, 112511U (2020) https://doi.org/10.1117/12.2548816

KEYWORDS: Cancer, Blood, Physiology, Biopsy, Cell biology, Medical research, Diagnostics, Tissues, Detector development, Chemistry

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Proceedings Article | 10 March 2020 Presentation

Presentation

Six-pack holography and dynamic synthetic aperture superresolution (Conference Presentation)

Simcha Mirsky, Natan Shaked

Proceedings Volume 11251, 112511L (2020) https://doi.org/10.1117/12.2548312

KEYWORDS: Holography, Super resolution, Holograms, Spatial frequencies, Sensors, Light sources, Multiplexing, Cameras, Image resolution, Blood

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Proceedings Article | 9 March 2020 Presentation

Presentation

Water inspection using interferometric phase microscopy (Conference Presentation)

Natan Shaked

Proceedings Volume 11233, 112330G (2020) https://doi.org/10.1117/12.2554399

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Proceedings Article | 9 March 2020 Open Access

Open Access

Presentation

Machine-learning with a small training set for classification of quantitative phase images of cancer cells (Conference Presentation)

Natan Shaked

Proceedings Volume 11299, 112990Q (2020) https://doi.org/10.1117/12.2550957

KEYWORDS: Cancer, Machine learning, Image classification, Microscopy, Refractive index, Medical imaging, Interferometry, Phase interferometry, Tomography, Wavefronts

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Proceedings Article | 10 September 2019 Presentation

Presentation

Classification of quantitative phase images of cancer cells using machine learning (Conference Presentation)

Natan Shaked

Proceedings Volume 11139, 111390Z (2019) https://doi.org/10.1117/12.2530990

KEYWORDS: Cancer, Machine learning, Image classification, Refractive index, Interferometry, Phase interferometry, Microscopy, Tomography, Wavefront sensors, Phase contrast

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Proceedings Article | 21 June 2019 Paper

Paper

Wound healing assay of two competing cell types with dry mass measurement

Shir Cohen Maslaton, Natan Shaked

Proceedings Volume 11060, 110600Z (2019) https://doi.org/10.1117/12.2526841

KEYWORDS: Wound healing, Microscopes, Interferometry, Microscopy, Green fluorescent protein, Holograms, Phase interferometry, Refractive index, Imaging systems

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Proceedings Article | 4 March 2019 Presentation

Presentation

Single-exposure label-free multi-wavelength quantitative phase imaging using spatial multiplexing (Conference Presentation)

Nir Turko, Natan Shaked

Proceedings Volume 10890, 1089022 (2019) https://doi.org/10.1117/12.2506100

KEYWORDS: Multiplexing, Phase imaging, Interferometry, Light sources, Cameras, Data acquisition, Spectroscopy

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Proceedings Article | 24 May 2018 Paper

Paper

Quantitative phase microscopy of dynamic cells using off-axis holographic compression by spatial multiplexing

Natan Shaked

Proceedings Volume 10677, 106770H (2018) https://doi.org/10.1117/12.2304586

KEYWORDS: Holograms, Multiplexing, Holography, Cameras, Digital holography, Wavefronts, Beam splitters, Microscopy, Optical multiplexing, Retroreflectors

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Proceedings Article | 15 March 2018 Presentation

Presentation

Multiple depth multiplexing in off-axis low-coherence interferometric imaging (Conference Presentation)

Lauren Wolbromsky, Natan Shaked

Proceedings Volume 10503, 105030A (2018) https://doi.org/10.1117/12.2286846

KEYWORDS: Interferometry, Multiplexing, Holographic interferometry, Holography, Imaging systems, Phase imaging, Image acquisition, Digital cameras, Optical multiplexing, Cameras

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Proceedings Article | 28 July 2017 Paper

Paper

Multi-modal and photothermal quantitative phase imaging of living cells with nanoparticles in a combined setup

Nir Turko, Michael Isbach, Steffi Ketelhut, Burkhard Greve, Jürgen Schnekenburger, Natan Shaked, Björn Kemper

Proceedings Volume 10414, 104140E (2017) https://doi.org/10.1117/12.2286169

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Proceedings Article | 26 June 2017 Paper

Paper

Autonomous generation of extended images of dynamic phase objects in a depth volume sample using a simple focusing criterion and K-means clustering

Maria-Luisa Cruz, Miguel Alcaraz-Rivera, Pinhas Girshovitz, Natan Shaked, Bahram Javidi

Proceedings Volume 10335, 103350Z (2017) https://doi.org/10.1117/12.2270359

KEYWORDS: Biological research, Image processing, Digital holography, Image segmentation, Holograms, Optical signal processing, Video, Microbiology, Holography, Microscopy, Statistical analysis

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SPIE Journal Paper | 21 June 2017 Open Access

Open Access

Dynamic measurements of flowing cells labeled by gold nanoparticles using full-field photothermal interferometric imaging

Nir Turko, Darina Roitshtain, Omry Blum, Björn Kemper, Natan Shaked

JBO, Vol. 22, Issue 06, 066012, (June 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.6.066012

KEYWORDS: Interferometry, Nanoparticles, Gold, Phase interferometry, Microscopy, Algorithm development, Live cell imaging, Plasmons, Phase imaging, Real time imaging

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Proceedings Article | 24 April 2017 Presentation

Presentation

Photothermal nanoparticles as molecular specificity agents in interferometric phase microscopy (Conference Presentation)

Natan Shaked

Proceedings Volume 10077, 100770T (2017) https://doi.org/10.1117/12.2249551

KEYWORDS: Microscopy, Nanoparticles, Interferometry, Plasmonics, Phase measurement, Phase imaging, Cancer, Blood, Imaging systems, Phase interferometry

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Proceedings Article | 24 April 2017 Presentation

Presentation

Quantitative phase microscopy of cells in flow using flipping interferometry (Conference Presentation)

Natan Shaked, Bahram Javidi, Nir Turko, Darina Roitshtain

Proceedings Volume 10074, 1007411 (2017) https://doi.org/10.1117/12.2252341

KEYWORDS: Phase imaging, Current controlled current source, Interferometry, Microscopy, Medical diagnostics, Image acquisition, Biological research, Phase interferometry, Microfluidics

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Proceedings Article | 24 April 2017 Presentation

Presentation

Phase unwrapping using a portable two wavelength multiplexing module (Conference Presentation)

Nir Turko, Natan Shaked

Proceedings Volume 10074, 100740M (2017) https://doi.org/10.1117/12.2256087

KEYWORDS: Current controlled current source, Multiplexing, Phase imaging, Image processing, Biology, Metrology, Interferometry, Microscopy, Microscopes

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Proceedings Article | 21 February 2017 Paper

Paper

Photothermal quantitative phase imaging of living cells with nanoparticles utilizing a cost-efficient setup

Nir Turko, Michael Isbach, Steffi Ketelhut, Burkhard Greve, Jürgen Schnekenburger, Natan Shaked, Björn Kemper

Proceedings Volume 10074, 100740Q (2017) https://doi.org/10.1117/12.2252873

KEYWORDS: Holograms, Phase imaging, Digital holography, Nanoparticles, Holography, Microscopy, Refractive index, Gold, Image segmentation, Breast cancer, Microscopes

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Proceedings Article | 26 May 2016 Presentation

Presentation

Using quantitative interference phase microscopy for sperm acrosome evaluation (Conference Presentation)

Michal Balberg, Ksawery Kalinowski, Mattan Levi, Natan Shaked

Proceedings Volume 9718, 97180W (2016) https://doi.org/10.1117/12.2216724

KEYWORDS: Microscopy, Phase imaging, Current controlled current source

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Proceedings Article | 27 April 2016 Presentation

Presentation

GPU-based rapid reconstruction of cellular 3D refractive index maps from tomographic phase microscopy (Conference Presentation)

Gili Dardikman, Natan Shaked

Proceedings Volume 9718, 97180G (2016) https://doi.org/10.1117/12.2209315

KEYWORDS: 3D visualizations, Reconstruction algorithms, Refractive index, Tomography, Microscopy, Computer programming, Interferometry, Graphics processing units, Wavefronts, Fourier transforms

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Proceedings Article | 27 April 2016 Presentation

Presentation

Label-free 3D refractive-index acquisition by micro-manipulations of cells in suspension (Conference Presentation)

Natan Shaked

Proceedings Volume 9718, 971804 (2016) https://doi.org/10.1117/12.2209306

KEYWORDS: 3D acquisition, Interferometry, Tomography, Microscopy, Diffraction, 3D image processing, Inspection, Phase imaging, Current controlled current source

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Proceedings Article | 27 April 2016 Presentation

Presentation

Multimodal interferometric microscopy for label-free 3D imaging of live cells in flow (Conference Presentation)

Natan Tzvi Shaked

Proceedings Volume 9713, 97130C (2016) https://doi.org/10.1117/12.2214447

KEYWORDS: Interferometry, Microscopy, Stereoscopy, Reconstruction algorithms, Holographic interferometry, Holography, Optical tweezers, Tomography, Diffraction, Image analysis

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Proceedings Article | 17 March 2016 Presentation + Paper

Presentation + Paper

Dynamic photothermal interferometric phase microscopy

Nir Turko, Omry Blum, Natan Shaked

Proceedings Volume 9713, 97131G (2016) https://doi.org/10.1117/12.2212403

KEYWORDS: Microscopy, Nanoparticles, Interferometry, Phase interferometry, Gold, Fourier transforms, Algorithm development, Holography, Plasmons, Real time imaging, Signal to noise ratio, Cameras, Image processing, Mirrors

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Proceedings Article | 9 March 2016 Presentation + Paper

Presentation + Paper

Analyzing the texture changes in the quantitative phase maps of adipocytes

Darina Roitshtain, Orna Sharabani-Yosef, Amit Gefen, Natan Shaked

Proceedings Volume 9718, 97180R (2016) https://doi.org/10.1117/12.2209317

KEYWORDS: Microscopy, Interferometry, Refractive index, Volume rendering, Phase interferometry, Wavelets, Visualization, Interferometers, Mode conditioning cables, Proteins, Biological research, Wavelet transforms, Spatial resolution, Optical spheres

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SPIE Journal Paper | 6 October 2015 Open Access

Open Access

Broadband quantitative phase microscopy with extended field of view using off-axis interferometric multiplexing

Pinhas Girshovitz, Irena Frenklach, Natan Shaked

JBO, Vol. 20, Issue 11, 111217, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.11.111217

KEYWORDS: Interferometry, Multiplexing, Cameras, Interferometers, Microscopy, Imaging systems, Retroreflectors, Wavefronts, Microscopes, Digital cameras

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Proceedings Article | 14 July 2015 Paper

Paper

Tomographic phase microscopy using optical tweezers

Mor Habaza, Barak Gilboa, Yael Roichman, Natan Shaked

Proceedings Volume 9536, 95360H (2015) https://doi.org/10.1117/12.2183708

KEYWORDS: Optical tweezers, Tomography, Microscopy, Refractive index, Yeast, Diffraction, 3D image processing, Interferometry, Holography, Optical microscopy

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Proceedings Article | 11 March 2015 Paper

Paper

Fast processing of quantitative phase profiles from off-axis interferograms for real-time applications

Pinhas Girshovitz, Natan Shaked

Proceedings Volume 9336, 93360W (2015) https://doi.org/10.1117/12.2079754

KEYWORDS: Reconstruction algorithms, Fourier transforms, Visualization, Evolutionary algorithms, Computer programming, Digital holography, Image processing, Multiplexing, Parallel computing, Einsteinium

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Proceedings Article | 11 March 2015 Paper

Paper

Multiplexed off-axis interferometric phase microscopy for dynamic cell measurements

Natan Shaked, Pinhas Girshovitz, Irena Frenklach

Proceedings Volume 9336, 93360B (2015) https://doi.org/10.1117/12.2078227

KEYWORDS: Cameras, Interferometry, Multiplexing, Beam splitters, Retroreflectors, Sensors, Digital cameras, Microscopes, Mirrors, Phase interferometry

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Proceedings Article | 9 March 2015 Paper

Paper

Dual-modality wide-field photothermal quantitative phase microscopy and depletion of cell populations

Nir Turko, Itay Barnea, Omry Blum, Rafi Korenstein, Natan Shaked

Proceedings Volume 9330, 933016 (2015) https://doi.org/10.1117/12.2078144

KEYWORDS: Microscopy, Cancer, Imaging systems, Plasmonics, Blood, Nanoparticles, Cameras, Gold, Mirrors, Phase imaging

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Proceedings Article | 18 August 2014 Paper

Paper

ITIA: tripling the field-of-view in off-axis interferometric phase microscopy

Irena Frenklach, Pinhas Girshovitz, Natan Shaked

Proceedings Volume 9203, 920307 (2014) https://doi.org/10.1117/12.2064444

KEYWORDS: Interferometry, Beam splitters, Cameras, Multiplexing, Einsteinium, Microscopes, Retroreflectors, Erbium, Phase interferometry, Microscopy

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Proceedings Article | 18 August 2014 Paper

Paper

Real-time processing of off-axis interferograms: from the camera to the user

Pinhas Girshovitz, Tamir Gabay, Natan Shaked

Proceedings Volume 9203, 920304 (2014) https://doi.org/10.1117/12.2064447

KEYWORDS: Reconstruction algorithms, Fourier transforms, Digital holography, Multiplexing, Visualization, Cameras, Holography, Wavefronts, Holograms, Digital recording

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Proceedings Article | 18 August 2014 Paper

Paper

IDIA: doubling the recorded imaging area or the frame rate in off-axis interferometric microscopy

Pinhas Girshovitz, Natan Shaked

Proceedings Volume 9203, 920319 (2014) https://doi.org/10.1117/12.2064454

KEYWORDS: Interferometry, Cameras, Einsteinium, Microscopes, Multiplexing, Erbium, Holography, Interferometers, Brain mapping, Retroreflectors

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Proceedings Article | 5 June 2014 Paper

Paper

Portable low-coherence interferometry for quantitatively imaging fast dynamics with extended field of view

Natan Shaked, Pinhas Girshovitz, Irena Frenklach

Proceedings Volume 9117, 911709 (2014) https://doi.org/10.1117/12.2051285

KEYWORDS: Cameras, Interferometry, Beam splitters, Wavefronts, Retroreflectors, Multiplexing, Microscopes, Sensors, Mirrors, Interferometers

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Proceedings Article | 12 March 2014 Paper

Paper

Reflective interferometric system combining low-coherence spectral-domain phase microscopy and wide-field holography for characterization of thin samples

Reut Friedman, Natan Shaked

Proceedings Volume 8949, 89491F (2014) https://doi.org/10.1117/12.2038416

KEYWORDS: Interferometers, Interferometry, Microscopy, Reflectivity, Imaging systems, Cameras, Phase measurement, Beam splitters, Microscopes, Holography

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SPIE Journal Paper | 2 December 2013 Open Access

Open Access

Special Section Guest Editorial: Optical Imaging, Sensing, and Light Interactions in Cells and Tissues

Natan Shaked, Shy Shoham, Bruce Tromberg, Israel Gannot

JBO, Vol. 18, Issue 11, 111401, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.11.111401

KEYWORDS: Biomedical optics, Optical sensing, Optical imaging, Tissues, Remote sensing, Confocal microscopy, Microscopy, Translational research, Optical coherence tomography, Neurophotonics

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SPIE Journal Paper | 27 September 2013 Open Access

Open Access

Wide-field interferometric phase microscopy with molecular specificity using plasmonic nanoparticles

Nir Turko, Anna Peled, Natan Shaked

JBO, Vol. 18, Issue 11, 111414, (September 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.11.111414

KEYWORDS: Confocal microscopy, Interferometry, Phase interferometry, Microscopy, Imaging systems, Nanoparticles, Absorption, Microscopes, Plasmonics, Refractive index

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Proceedings Article | 23 May 2013 Paper

Paper

Optical-mechanical properties of diseased cells measured by interferometry

Natan Shaked, Y. Bishitz, H. Gabai, P. Girshovitz

Proceedings Volume 8792, 87921G (2013) https://doi.org/10.1117/12.2021477

KEYWORDS: Cancer, Refractive index, Interferometry, Phase interferometry, Microscopy, In vitro testing, Optical tracking, Optical testing, Blood, Colorectal cancer

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Proceedings Article | 23 May 2013 Paper

Paper

Non-invasive continuous imaging of drug release from soy-based skin equivalent using wide-field interferometry

Haniel Gabai, Maya Baranes-Zeevi, Meital Zilberman, Natan Shaked

Proceedings Volume 8792, 879215 (2013) https://doi.org/10.1117/12.2020485

KEYWORDS: Interferometry, Imaging systems, Polymers, In vitro testing, Skin, In vivo imaging, Silicon, Refractive index, Cameras, Proteins

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Proceedings Article | 22 February 2013 Paper

Paper

Portable low-coherence interferometer for quantitative phase microscopy of live cells

Natan Shaked, Pinhas Girshovitz

Proceedings Volume 8589, 858913 (2013) https://doi.org/10.1117/12.2001758

KEYWORDS: Interferometers, Microscopes, Microscopy, Interferometry, Optical components, Cameras, Phase interferometry, Blood, Mirrors, Mach-Zehnder interferometers

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Proceedings Article | 21 February 2013 Paper

Paper

Wide-field interferometric phase imaging of plasmonic nanoparticles at the subcellular level

Nir Turko, Ania Peled, Natan Shaked

Proceedings Volume 8597, 85970O (2013) https://doi.org/10.1117/12.2002942

KEYWORDS: Interferometry, Imaging systems, Nanoparticles, Plasmonics, Absorption, Statistical analysis, Gold, Holography, Microscopes, Particles

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SPIE Journal Paper | 13 June 2012 Open Access

Open Access

Optical phase nanoscopy in red blood cells using low-coherence spectroscopy

Itay Shock, Pinhas Girshovitz, Uri Nevo, Natan Shaked, Alexander Barbul, Rafi Korenstein

JBO, Vol. 17, Issue 10, 101509, (June 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.10.101509

KEYWORDS: Blood, Microscopy, Spectroscopy, Super resolution microscopy, Digital holography, Interferometry, Phase measurement, Biomedical optics, Holographic interferometry, Holography

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Proceedings Article | 3 February 2012 Paper

Paper

Dynamic quantitative microscopy and nanoscopy of red blood cells in sickle cell disease

Natan Shaked, Lisa Satterwhite, Marilyn Telen, George Truskey, Adam Wax

Proceedings Volume 8227, 822711 (2012) https://doi.org/10.1117/12.907659

KEYWORDS: Single crystal X-ray diffraction, Blood, Microscopy, Refractive index, Objectives, Microscopes, Interferometry, Digital holography, Holography, Einsteinium

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Proceedings Article | 2 February 2012 Paper

Paper

Optical phase measurements in red blood cells using low-coherence spectroscopy

Itay Shock, Alexander Barbul, Pinhas Girshovitz, Uri Nevo, Rafi Korenstein, Natan Shaked

Proceedings Volume 8230, 82300D (2012) https://doi.org/10.1117/12.907262

KEYWORDS: Microscopy, Blood, Phase measurement, Digital holography, Interferometry, Holography, Spectroscopy, Signal to noise ratio, Holographic interferometry, Liquids

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Proceedings Article | 20 May 2011 Paper

Paper

Quantitative analysis of three-dimensional biological cells using interferometric microscopy

Natan Shaked, Adam Wax

Proceedings Volume 8043, 80430U (2011) https://doi.org/10.1117/12.882357

KEYWORDS: Refractive index, Microscopy, Phase measurement, Quantitative analysis, Holography, Interferometry, Visualization, Digital holography, In vitro testing, Digital image correlation

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SPIE Journal Paper | 1 March 2011 Open Access

Open Access

Quantitative microscopy and nanoscopy of sickle red blood cells performed by wide field digital interferometry

Natan Shaked, Lisa Satterwhite, George Truskey, Adam Wax, Marilyn Telen

JBO, Vol. 16, Issue 03, 030506, (March 2011) https://doi.org/10.1117/12.10.1117/1.3556717

KEYWORDS: Blood, Interferometry, Microscopy, Super resolution microscopy, Video, Refractive index, Genetics, Therapeutic agents, Biomedical engineering, Photonics

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Proceedings Article | 1 March 2011 Paper

Paper

Whole cell imaging based on wide-field interferometric phase microscopy and its application to cardiomyocytes

Natan Shaked, Lisa Satterwhite, Nenad Bursac, Adam Wax

Proceedings Volume 7904, 790405 (2011) https://doi.org/10.1117/12.874224

KEYWORDS: Refractive index, Microscopy, Interferometry, Digital holography, Holography, Objectives, Einsteinium, Erbium, Phase interferometry, Biological research

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SPIE Journal Paper | 1 May 2010 Open Access

Open Access

Reflective interferometric chamber for quantitative phase imaging of biological sample dynamics

Natan Shaked, Yizheng Zhu, Nima Badie, Nenad Bursac, Adam Wax

JBO, Vol. 15, Issue 03, 030503, (May 2010) https://doi.org/10.1117/12.10.1117/1.3420179

KEYWORDS: Interferometry, Phase imaging, Interferometers, Reflectivity, Optical components, Phase measurement, Transmittance, Coating, Beam splitters, Digital cameras

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SPIE Journal Paper | 1 January 2010 Open Access

Open Access

Quantitative phase microscopy of articular chondrocyte dynamics by wide-field digital interferometry

Natan Shaked, John Finan, Farshid Guilak, Adam Wax

JBO, Vol. 15, Issue 01, 010505, (January 2010) https://doi.org/10.1117/12.10.1117/1.3290242

KEYWORDS: Microscopy, Interferometry, Digital image correlation, Visualization, Video, Wavefronts, Cameras, Cartilage, Quantitative analysis, Phase interferometry

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Proceedings Article | 15 April 2008 Paper

Paper

Holography of incoherently illuminated 3D scenes

Natan Shaked, Joseph Rosen

Proceedings Volume 6983, 69830Q (2008) https://doi.org/10.1117/12.786894

KEYWORDS: Holograms, Digital holography, Point spread functions, Cameras, Holography, 3D image reconstruction, Digital cameras, 3D acquisition, Microlens, Fourier transforms

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SPIE Journal Paper | 1 October 2007

Optical binary-matrix synthesis for solving bounded NP-complete combinatorial problems

Natan Shaked, Tal Tabib, Simon Gil, Stephane Messika, Shlomi Dolev, Joseph Rosen

OE, Vol. 46, Issue 10, 108201, (October 2007) https://doi.org/10.1117/12.10.1117/1.2799086

KEYWORDS: Binary data, Optical engineering, Spatial light modulators, Chemical elements, Detection and tracking algorithms, Optical filters, Matrices, CCD cameras, Diffraction, Optical correlators

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Proceedings Article | 30 August 2006 Paper

Paper

Optical processor for solving the traveling salesman problem (TSP)

Natan Shaked, Gil Simon, Tal Tabib, Stephane Mesika, Shlomi Dolev, Joseph Rosen

Proceedings Volume 6311, 63110G (2006) https://doi.org/10.1117/12.683979

KEYWORDS: Spatial light modulators, Detection and tracking algorithms, CCD cameras, Diffraction, Optical filters, Fourier transforms, Optical correlators, Convolution, Computer simulations, Optical simulations

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Proceedings Article | 13 August 1993 Paper

Paper

Faraday-rotation fiber optic current sensor: response to different locations of the conductor

Moshe Tur, Amit Ben-kish, Ehud Shafir, N. Shaked

Proceedings Volume 1972, (1993) https://doi.org/10.1117/12.151119

KEYWORDS: Birefringence, Sensors, Fiber optics sensors, Fiber optics, Polarization, Measurement devices, Optical engineering, Magnetism, Polarizers, Fiber optics tests

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Showing 5 of 70 publications

Proceedings Volume Editor (6)

SPIE Conference Volume | 29 March 2024

Label-free Biomedical Imaging and Sensing (LBIS) 2024

SPIE Conference Volume | 26 April 2023

Label-free Biomedical Imaging and Sensing (LBIS) 2023

SPIE Conference Volume | 14 April 2022

Label-free Biomedical Imaging and Sensing (LBIS) 2022

SPIE Conference Volume | 14 April 2021

Label-free Biomedical Imaging and Sensing (LBIS) 2021

SPIE Conference Volume | 17 March 2020

Label-free Biomedical Imaging and Sensing (LBIS) 2020

Showing 5 of 6 publications

Conference Committee Involvement (26)

Label-free Biomedical Imaging and Sensing (LBIS) 2025

25 January 2025 | San Francisco, United States

AI and Optical Data Sciences VI

25 January 2025 | San Francisco, United States

Three-Dimensional Imaging, Visualization, and Display 2024

22 April 2024 | National Harbor, Maryland, United States

Tissue Optics and Photonics III

9 April 2024 | Strasbourg, France

AI and Optical Data Sciences V

29 January 2024 | San Francisco, California, United States

Label-free Biomedical Imaging and Sensing (LBIS) 2024

27 January 2024 | San Francisco, California, United States

Optical Methods for Inspection, Characterization, and Imaging of Biomaterials VI

26 June 2023 | Munich, Germany

AI and Optical Data Sciences IV

30 January 2023 | San Francisco, California, United States

Label-free Biomedical Imaging and Sensing (LBIS) 2023

28 January 2023 | San Francisco, California, United States

Tissue Optics and Photonics II

5 April 2022 | Strasbourg, France

AI and Optical Data Sciences III

24 January 2022 | San Francisco, California, United States

Label-free Biomedical Imaging and Sensing (LBIS) 2022

23 January 2022 | San Francisco, California, United States

Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V

21 June 2021 | Online Only, Germany

AI and Optical Data Sciences II

6 March 2021 | Online Only, California, United States

Label-free Biomedical Imaging and Sensing (LBIS) 2021

6 March 2021 | Online Only, California, United States

Three-Dimensional Imaging, Visualization, and Display 2020

27 April 2020 | Online Only, California, United States

Tissue Optics and Photonics

7 April 2020 | Online Only, France

AI and Optical Data Sciences

4 February 2020 | San Francisco, California, United States

Label-free Biomedical Imaging and Sensing (LBIS) 2020

1 February 2020 | San Francisco, California, United States

Optical Methods for Inspection, Characterization, and Imaging of Biomaterials IV

24 June 2019 | Munich, Germany

Three-Dimensional Imaging, Visualization, and Display 2019

15 April 2019 | Baltimore, MD, United States

Label-free Biomedical Imaging and Sensing (LBIS) 2019

2 February 2019 | San Francisco, California, United States

Optical Methods for Inspection, Characterization, and Imaging of Biomaterials

26 June 2017 | Munich, Germany

Optical Methods for Inspection, Characterization, and Imaging of Biomaterials II

22 June 2015 | Munich, Germany

Optical Methods for Inspection, Characterization, and Imaging of Biomaterials

15 May 2013 | Munich, Germany

1st International Biophotonics Meeting in Israel

9 December 2012 | Tel Aviv, Israel

Showing 5 of 26 Conference Committees

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