Liposomal nanoparticles enhance contrast of fluorescence, speckle-contrast imaging, and ultrasound measurements in phantoms and murine model

Olga A. Stelmashchuk; Andrey Vinokurov; Mikhail Apanaykin; Igor Kozlov; Andrian Mamoshin; A. Borsukov; Andrey V. Dunaev

doi:10.1117/12.2555973

2 April 2020 Liposomal nanoparticles enhance contrast of fluorescence, speckle-contrast imaging, and ultrasound measurements in phantoms and murine model

Olga A. Stelmashchuk, Andrey Vinokurov, Mikhail Apanaykin, Igor Kozlov, Andrian Mamoshin, A. Borsukov, Andrey V. Dunaev

Author Affiliations +

Proceedings Volume 11363, Tissue Optics and Photonics; 1136326 (2020) https://doi.org/10.1117/12.2555973
Event: SPIE Photonics Europe, 2020, Online Only

Abstract

Liposomal particles are used as an instrument for drug delivery and as fluorescent labels. Due to its properties, liposomal particles can be used as a dual-purpose contrast agent both in fluorescence imaging, laser speckle contrast imaging and ultrasound diagnostics. Liposomes obtained by one purpose but subsequently contained a fluorescent label or air. This work aimed to prepare liposomal particles and to study possibilities of its application for the dual-use in fluorescence spectroscopy and ultrasound diagnostics. In this work, we used fluorescence spectroscopy to investigate the efficiency of propagation in the circulatory system of fluorescent-labelled liposome nanocapsules loaded with eosin-Y (disodium salt of 2,4,5,7 tetrabromofluorescein These results demonstrate that liposomal particles can be used in fluorescence spectroscopy, in ultrasound diagnostics and in LSCI. It may find the application in the field of drug delivery control and high-throughput screening during drug development.

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Olga A. Stelmashchuk, Andrey Vinokurov, Mikhail Apanaykin, Igor Kozlov, Andrian Mamoshin, A. Borsukov, and Andrey V. Dunaev "Liposomal nanoparticles enhance contrast of fluorescence, speckle-contrast imaging, and ultrasound measurements in phantoms and murine model", Proc. SPIE 11363, Tissue Optics and Photonics, 1136326 (2 April 2020); https://doi.org/10.1117/12.2555973

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