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5 March 2021 Ex vivo and in vivo validation of the murine inner retinal cellular morphology visualized by in-vivo temporal speckle averaging optical coherence tomography (TSA-OCT)
Pengfei Zhang, Olga Vafaeva, Christian Dolf, Nicholas Marsh-Armstrong, Robert Zawadzki
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Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116230N (2021) https://doi.org/10.1117/12.2579267
Event: SPIE BiOS, 2021, Online Only
Abstract
It has been recently demonstrated that structures corresponding to the cell bodies of highly transparent cells in the retinal ganglion cell layer could be visualized noninvasively both in the living human and mouse eyes by optical coherence tomography (OCT) via temporal averaging. Here, we further explored the application of volumetric temporal averaging in mice, with a focus on correlating the in vivo results with the ex vivo histology, on the same retinas, to verify the structures seen in the in vivo images, which will help to better understand the pathophysiology of these cells.
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Pengfei Zhang, Olga Vafaeva, Christian Dolf, Nicholas Marsh-Armstrong, and Robert Zawadzki "Ex vivo and in vivo validation of the murine inner retinal cellular morphology visualized by in-vivo temporal speckle averaging optical coherence tomography (TSA-OCT)", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230N (5 March 2021); https://doi.org/10.1117/12.2579267
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KEYWORDS
In vivo imaging
Optical coherence tomography
Visualization
Speckle
Adaptive optics
Imaging systems
Image quality
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