Visualization of disrupted chromatin folding at nanoscale in early carcinogenesis via super-resolution microscopy

Yang Liu; Jianquan Xu; Hongqiang Ma

doi:10.1117/12.2579259

5 March 2021 Visualization of disrupted chromatin folding at nanoscale in early carcinogenesis via super-resolution microscopy

Yang Liu, Jianquan Xu, Hongqiang Ma

Author Affiliations +

Proceedings Volume 11647, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX; 1164715 (2021) https://doi.org/10.1117/12.2579259
Event: SPIE BiOS, 2021, Online Only

Abstract

I will present our recent development of high-throughput super-resolution microscopy for robust imaging and reconstruction of super-resolution images on a widely used type of clinical samples – formalin-fixed, paraffin-embedded (FFPE) tissue, referred to as PathSTORM. Its application to visualize disrupted higher-order chromatin folding in early carcinogenesis will also be discussed.

Conference Presentation

Citation Download Citation

Yang Liu, Jianquan Xu, and Hongqiang Ma "Visualization of disrupted chromatin folding at nanoscale in early carcinogenesis via super-resolution microscopy", Proc. SPIE 11647, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, 1164715 (5 March 2021); https://doi.org/10.1117/12.2579259

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