Multispectral imaging quantifies available immune-inhibitory receptor concentrations for therapeutic binding of anti-PD-1 checkpoint inhibitors

Divya Ravi; Abdibaset A. Bare; Emma M. Cammack; Veronica C. Torres; Kimberley S Samkoe

doi:10.1117/12.2650637

17 March 2023 Multispectral imaging quantifies available immune-inhibitory receptor concentrations for therapeutic binding of anti-PD-1 checkpoint inhibitors

Divya Ravi, Abdibaset A. Bare, Emma M. Cammack, Veronica C. Torres, Kimberley S Samkoe

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Proceedings Volume 12357, Visualizing and Quantifying Drug Distribution in Tissue VII; 123570H (2023) https://doi.org/10.1117/12.2650637
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Immune checkpoint inhibitors (ICIs) are among the most effective classes of cancer immunotherapies yet only a small minority of patients derive clinical benefit. We are investigating the use of multi-spectral paired-agent imaging (mPAI) to quantify available PD-1 and PD-L1 receptor concentrations for the therapeutic binding of anti-PD-1 checkpoint inhibitors.

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Divya Ravi, Abdibaset A. Bare, Emma M. Cammack, Veronica C. Torres, and Kimberley S Samkoe "Multispectral imaging quantifies available immune-inhibitory receptor concentrations for therapeutic binding of anti-PD-1 checkpoint inhibitors", Proc. SPIE 12357, Visualizing and Quantifying Drug Distribution in Tissue VII, 123570H (17 March 2023); https://doi.org/10.1117/12.2650637

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KEYWORDS

Receptors

Multispectral imaging

Tumors

Tissues

Cancer

Flow cytometry

In vivo imaging

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