Mapping of coherent cerebral hemodynamics with dual-slope imaging

Cristianne Fernandez; Giles Blaney; Angelo Sassaroli; Tapan Das; Sergio Fantini

doi:10.1117/12.2652107

7 March 2023 Mapping of coherent cerebral hemodynamics with dual-slope imaging

Cristianne Fernandez, Giles Blaney, Angelo Sassaroli, Tapan Das, Sergio Fantini

Proceedings Volume 12376, Optical Tomography and Spectroscopy of Tissue XV; 123760I (2023) https://doi.org/10.1117/12.2652107
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Cerebral hemodynamics, measured with near-infrared spectroscopy, that are coherent with changes in blood pressure can be analyzed with Coherent Hemodynamics Spectroscopy (CHS). Performing diffuse optical imaging during a CHS protocol provides the ability to spatially map cerebral hemodynamics and elucidate their relation to blood flow and blood volume dynamics. Here, we apply frequency-domain dual-slope optical imaging during a CHS protocol to demonstrate the preferential sensitivity to cerebral hemodynamics of dual-slope frequency-domain measurements as compared to traditional single-distance intensity measurements. Specifically, the results show that dual-slope phase measurements recorded hemodynamics that are mostly associated with blood-flow oscillations (as expected in the brain), while single distance intensity measurements recorded hemodynamics that are mostly associated with blood-volume oscillations (as expected in the scalp). Reconstructed dual-slope phase images showed the effect of a spatially variable skull thickness, which can cause heterogeneity within the reconstructed images. Future work will include measurements on multiple subjects and across multiple oscillation frequencies to further investigate the spatial distribution and frequency dependence of cerebral hemodynamic oscillations.

Conference Presentation

Citation Download Citation

Cristianne Fernandez, Giles Blaney, Angelo Sassaroli, Tapan Das, and Sergio Fantini "Mapping of coherent cerebral hemodynamics with dual-slope imaging", Proc. SPIE 12376, Optical Tomography and Spectroscopy of Tissue XV, 123760I (7 March 2023); https://doi.org/10.1117/12.2652107

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