Optical detection of structural alteration of brain tissues in Parkinson's disease via Partial Wave Spectroscopy (PWS)

Ishmael Apachigawo; Fatemah Alharthi; Mohammad Moshahid Khan; Prabhakar Pradhan

doi:10.1117/12.2650506

7 March 2023 Optical detection of structural alteration of brain tissues in Parkinson's disease via Partial Wave Spectroscopy (PWS)

Ishmael Apachigawo, Fatemah Alharthi, Mohammad Moshahid Khan, Prabhakar Pradhan

Author Affiliations +

Proceedings Volume 12377, Optical Interactions with Tissue and Cells XXXIV; 123770G (2023) https://doi.org/10.1117/12.2650506
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder, characterized by degeneration of dopaminergic neurons in the substantia nigra of the midbrain and loss of both motor and non-motor features. We apply photonics techniques for the characterization of structural changes in brain cells/tissues in progressive PD. In particular, we use mesoscopic optical physics-based finer-focused partial wave spectroscopy (PWS) technique to quantify the nano to submicron scales structural alterations in the brain tissues. Initial results show a change in structural disorder (Ld) as well as in the nuclear DNA spatial mass density in brain tissues of PD patients due to density fluctuations.

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Ishmael Apachigawo, Fatemah Alharthi, Mohammad Moshahid Khan, and Prabhakar Pradhan "Optical detection of structural alteration of brain tissues in Parkinson's disease via Partial Wave Spectroscopy (PWS)", Proc. SPIE 12377, Optical Interactions with Tissue and Cells XXXIV, 123770G (7 March 2023); https://doi.org/10.1117/12.2650506

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