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Vertical nanostructures have been studied extensively and been reported to induce unique responses in cells, including the formation of clathrin coating and accumulation of actin filament which leads to cell membrane curvature around the nanostructures. In our previous works, we have demonstrated that arrays of plasmonic nanoantenna can be used as effective label free biosensors to study live cells when combined with IR spectroscopy in the reflection mode, known as metasurface enhanced IR spectroscopy (MEIRS). By fabricating these plasmonic metasurfaces on top of silica nanopillars, we demonstrate that we can expand the potential of MEIRS: increased protein IR absorption in the amide band and increased sensitivity of our biosensor to processes involving cellular interaction with vertical nanostructures.
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Aditya Mahalanabish, Steven H. Huang, Gennady Shvets, "Metasurface enhanced infrared spectroscopy using vertical nanostructures," Proc. SPIE 12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, 123910H (16 March 2023); https://doi.org/10.1117/12.2650689