The crosstalk between the “inflamed” mind and the “impulsive” mind: activation of microglia and impulse control disorders

Yongqi Luo

doi:10.1117/12.2669957

24 March 2023 The crosstalk between the “inflamed” mind and the “impulsive” mind: activation of microglia and impulse control disorders

Yongqi Luo

Author Affiliations +

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126112H (2023) https://doi.org/10.1117/12.2669957
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Impulse control disorder(ICD) is a psychiatric disease characterized by impulsivity, the tendency to act without enough thinking and the incapability to resist urges. The consequences of ICD are widespread, which not only hamper the normal life of individuals but also cause heavy burdens to society. Existing ICD treatment focuses on psychological therapies and neurotransmission-oriented pharmaceuticals, but the efficacy is not satisfactory, necessitating the exploration of a new therapeutic direction. It was not until recently that neuroinflammation was revealed to be associated with ICD. Persistent activation of microglia, one of the typical characteristics of neuroinflammation, has been reported widely in impulsivity studies in human and animal models. Hence, this review has summarized clinical and pre-clinical evidence of microglial participation in ICD, and elucidated the mechanisms underlying the neuroinflammation-ICD relationship, focusing on cytokines and their impacts on neurotransmitters, neural substrates, and neurocircuits. The results: (1) recognize limitations of existing correlational evidence in supporting the causal claims; (2) propose areas for future clinical and experimental studies to determine the causal and mechanistic relationship between neuroinflammation and the development of impulsivity; (3) provide a possible novel direction, anti-neuroinflammation, for ICD treatment. In conclusion, microglia activation is closely associated with ICD, and anti-neuroinflammation might be the next therapeutic target for ICD treatment.

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Yongqi Luo "The crosstalk between the “inflamed” mind and the “impulsive” mind: activation of microglia and impulse control disorders", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126112H (24 March 2023); https://doi.org/10.1117/12.2669957

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KEYWORDS

Brain

Neurological disorders

Traumatic brain injury

Brain diseases

Inflammation

Modulation

Neurons

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