The role of NRG1 in schizophrenia

Jiaxuan Han; Jingnan Ru; Haoshen Zhai

doi:10.1117/12.2669672

24 March 2023 The role of NRG1 in schizophrenia

Jiaxuan Han, Jingnan Ru, Haoshen Zhai

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126112I (2023) https://doi.org/10.1117/12.2669672
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Schizophrenia, a fare mental disorder that affects up to 1% of the population among the world, is a significant topic being researched in recent years. Some researchers have found a gene called Neuregulin-1(NRG1) that may relate to schizophrenia. However, the role of NRG1 in schizophrenia has not yet been well explained. Therefore, this research essay collects information on NRG1 and schizophrenia and then analyzes the effects of NRG1 on neurons, such as excitatory/inhibitory neurotransmission. This essay would also focus on the treatments of schizophrenia, including pharmacological therapy and CRISPR-based evaluation of schizophrenia. In this case, the essay would research on the relationship between NRG1 and schizophrenia. As research shows, the NRG1 may negatively lead to schizophrenia genetically. The interaction between NRG1 and other substances in our brain, such as NMDAR or GABA released by interneurons. Treatments for schizophrenia could deal with this disease through two main pathways; nonpharmacological therapy and pharmacological therapy could help with easing the patient by releasing the symptoms. CRISPR, however, could deal with schizophrenia directly by editing a certain section of DNA. So people could either release the symptoms caused by the interaction of NRG1 with other receptors, or edit DNA information by CRISPR.

Citation Download Citation

Jiaxuan Han, Jingnan Ru, and Haoshen Zhai "The role of NRG1 in schizophrenia", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126112I (24 March 2023); https://doi.org/10.1117/12.2669672

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available