Dual-modal all-optical photoacoustic microscopy and viscoelasticity testing of soft tissues

Zijie Zhao; Zhiyu Yan; Cheng Fang; Jun Zou

doi:10.1117/12.3000776

12 March 2024 Dual-modal all-optical photoacoustic microscopy and viscoelasticity testing of soft tissues

Zijie Zhao, Zhiyu Yan, Cheng Fang, Jun Zou

Author Affiliations +

Proceedings Volume 12842, Photons Plus Ultrasound: Imaging and Sensing 2024; 128420P (2024) https://doi.org/10.1117/12.3000776
Event: SPIE BiOS, 2024, San Francisco, California, United States

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Abstract

This paper reports the development of dual-modal all-optical photoacoustic microscopy (PAM) and photoacoustic viscoelasticity testing (PAVT) based on a common setup with tunable annular-beam excitation and wideband laser-vibrometer detection. For PAM, the annular beam is reduced to a small diameter to excite longitudinal bulk acoustic waves (BAWs) from light-absorbing targets buried in the sample, and the imaging quality is improved by a specified synthetic aperture focusing technique (SAFT). For PAVT, circularly converging surface acoustic waves (SAWs) are generated on the sample surface by annular beams with larger and different diameters. Both the induced BAWs and SAWs are detected at the center of the annular beam in a non-contact fashion by a broad-band laser vibrometer. Experiments have been conducted on the tissue-mimicking agar phantoms as well as animal tissues and have successfully demonstrated the initial concept of dual-modal all-optical PAM and PAVT.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Zijie Zhao, Zhiyu Yan, Cheng Fang, and Jun Zou "Dual-modal all-optical photoacoustic microscopy and viscoelasticity testing of soft tissues", Proc. SPIE 12842, Photons Plus Ultrasound: Imaging and Sensing 2024, 128420P (12 March 2024); https://doi.org/10.1117/12.3000776

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