High-power UV laser photolysis of nucleosides: final product analysis

Dimitar A. Angelov; M. Berger; J. Cadet; Jean-Pierre Ballini; E. Keskinova; Paul Vigny

doi:10.1117/12.57289

1 May 1991 High-power UV laser photolysis of nucleosides: final product analysis

Dimitar A. Angelov, M. Berger, J. Cadet, Jean-Pierre Ballini, E. Keskinova, Paul Vigny

Proceedings Volume 1403, Laser Applications in Life Sciences; (1991) https://doi.org/10.1117/12.57289
Event: Laser Applications in Life Sciences, 1990, Moscow, Russian Federation

Abstract

Biophotonic excitation of purine and pyrimidine nucleobases becomes of increasingly importance as the laster intensity increases. Under these conditions the overall energy absorbed is much higher than the threshold energy required to generate pyrimidine and purine cathion radicals estimated to lies iin the 5-5.5 eV range (1). It is now communly accepted that the cathion radical is the primary damaging species generated upon two-quantum laser photolysis of nucleic acids derivatives. The chemistry of pyrimidine and purine cathion radicals in aqueous solutions has not been well udnerstood until recently. Two major exception delt with the initial chemical reaction of photo and ratioation - induced radical cation in low temperature thymine and thymidine - 5 - phosphate (2, 3) and at room temperature where the pyrimidine radical cathions were generated through an electron transfer reaction to photoexcited mendione in a triplet state.

Citation Download Citation

Dimitar A. Angelov, M. Berger, J. Cadet, Jean-Pierre Ballini, E. Keskinova, and Paul Vigny "High-power UV laser photolysis of nucleosides: final product analysis", Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); https://doi.org/10.1117/12.57289

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