Suppression of neointimal hyperplasia by photodynamic therapy: in vitro and in vivo results

Mohammed S. Sobeh; Philip Chan; Stephen E. Greenwald; Robert J. Ham; Alan J. Wood; Frank W. Cross M.D.; York N. Hsiang M.D.

doi:10.1117/12.179929

12 July 1994 Suppression of neointimal hyperplasia by photodynamic therapy: in vitro and in vivo results

Mohammed S. Sobeh, Philip Chan, Stephen E. Greenwald, Robert J. Ham, Alan J. Wood, Frank W. Cross M.D., York N. Hsiang M.D.

Author Affiliations +

Proceedings Volume 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV; (1994) https://doi.org/10.1117/12.179929
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

Proliferation of vascular smooth muscle cells (VSMCs) is the pathophysiogical basis of the restenoses which occur in 30-55% of patients undergone revascularisation. Prophylactic measures including pharmacotherapy, endovascular stenting and anti-gene therapy have so far failed to contain this problem. Photodynamic therapy (PDT) may selectively suppress VSMCs and decrease restenosis rates. We report 2 studies; the first examines the effect of PDT on an in-vitro model of NIH and the second involves using endoluminal ablation of an in-vivo model of experimental NIH of the rabbit's aorta.

Citation Download Citation

Mohammed S. Sobeh, Philip Chan, Stephen E. Greenwald, Robert J. Ham, Alan J. Wood, Frank W. Cross M.D., and York N. Hsiang M.D. "Suppression of neointimal hyperplasia by photodynamic therapy: in vitro and in vivo results", Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); https://doi.org/10.1117/12.179929

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