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18 January 1995 Light distribution in the endometrium during photodynamic therapy
Sten Madsen, Lars Othar Svaasand, Mathias K. Fehr, Yona Tadir M.D., Phat Ngo, Bruce J. Tromberg
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Proceedings Volume 2323, Laser Interaction with Hard and Soft Tissue II; (1995) https://doi.org/10.1117/12.199184
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France
Abstract
Hysterectomy is the most common major operation performed in the United States with dysfunctional uterine bleeding being a major indication. Endometrial destruction by photodynamic therapy (PDT) has been suggested as a possible alternative to invasive surgical procedures for abnormal uterine bleeding due to benign changes. Effective destruction of the endometrium during PDT requires a sufficient amount of light to be delivered to the entire endometrium in a reasonable time. To satisfy these criteria, we have developed a trifurcated optical applicator consisting of three cylindrical diffusing fibers. The applicator was inserted into freshly excised, intact human uteri and the optical distribution was measured with an isotropic fiber probe at various locations in the uterus. The results were in good agreement with the predictions of a mathematical model based on diffusion theory. The results indicate that irradiation of the endometrium by the trifurcated applicator can destroy tissue to a depth of 4 mm given an optical power of 100 mW per cm of diffusing tip (100 mW/cm) for an exposure time of less than 20 minutes.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Sten Madsen, Lars Othar Svaasand, Mathias K. Fehr, Yona Tadir M.D., Phat Ngo, and Bruce J. Tromberg "Light distribution in the endometrium during photodynamic therapy", Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); https://doi.org/10.1117/12.199184
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KEYWORDS
Optical fibers
Photodynamic therapy
Uterus
Tissue optics
Sensors
Diffusion
Tissues
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