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14 June 1999 Optical dosimetry in photodynamic therapy of human uterus and brain
Steen J. Madsen, Lars Othar Svaasand, Henry Hirschberg, Yona Tadir M.D., Bruce J. Tromberg
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Proceedings Volume 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical; (1999) https://doi.org/10.1117/12.350032
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Abstract
Optical 'dose' is one of the fundamental parameters required in the design of an efficacious regimen of photodynamic therapy (PDT). The issues involved in delivering a sufficient optical dose to the human uterus and brain during PDT will be discussed. Specifically, measurements of optical properties and fluence rates in excised human uteri are presented. Measured fluence rates are compared to the predictions of a simple diffusion model and the clinical utility of the treatment is discussed. The delivery of light to brain tissue via a surgically implanted balloon applicator will also be considered. The time required to deliver and adequate dose is calculated based on known optical properties and diffusion theory.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Steen J. Madsen, Lars Othar Svaasand, Henry Hirschberg, Yona Tadir M.D., and Bruce J. Tromberg "Optical dosimetry in photodynamic therapy of human uterus and brain", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); https://doi.org/10.1117/12.350032
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KEYWORDS
Optical properties
Photodynamic therapy
Tissue optics
Uterus
Brain
Sensors
Optical testing
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