Microsphere based saliva diagnostics

David M. Rissin; Christopher DiCesare; Ryan B. Hayman; Timothy M. Blicharz; David R. Walt

doi:10.1117/12.630781

11 November 2005 Microsphere based saliva diagnostics

David M. Rissin, Christopher DiCesare, Ryan B. Hayman, Timothy M. Blicharz, David R. Walt

Proceedings Volume 6007, Smart Medical and Biomedical Sensor Technology III; 60070X (2005) https://doi.org/10.1117/12.630781
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

Saliva presents a minimally invasive alternative medium to blood for performing diagnostics¹. Microsphere sensors for ions, small organic molecules, and proteins are currently being developed and optical microarrays containing thousands of these sensors will be used for simultaneous multi-analyte analysis. The fiber bundle platform in use is 1mm in diameter and contains approximately 50,000 individually addressable 3.1μm fibers, each with an etched well capable of housing a single 3.1μm microsphere sensor. Micron-sized bead-based chemistries are produced in house, followed by deposition onto a fiber-optic bundle platform, allowing for multiplexed analysis. The ultimate goal is to develop a universal diagnostic system using saliva as the diagnostic medium. This platform will permit multiplexed analysis of a sample by integrating microfluidics with the optical arrays loaded with sensors capable of detecting relevant biomarkers associated with a wide range of disease states. Disease states that are currently under investigation include end stage renal disease (ESRD) and Sjoegrens Syndrome (SS).

Citation Download Citation

David M. Rissin, Christopher DiCesare, Ryan B. Hayman, Timothy M. Blicharz, and David R. Walt "Microsphere based saliva diagnostics", Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 60070X (11 November 2005); https://doi.org/10.1117/12.630781

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